NOVEMBER 5, 2012

university of illinois CANCER CENTER
UPDATE

Becknma


News briefs


When Cancer Center and CCP program member, Dr. John Erdman, Jr., took on the responsibility of chairing the 2012 Annual Research Conference for the American Institute of Cancer Research (AICR), a hurricane was farthest from his mind.  But it was “Superstorm Sandy” that made more than a significant impact, forcing a complete cancellation of the conference.  As communities come together and rebuild, we are thinking of our friends on the Eastern seaboard, who are tiptoeing through lost power, minimal transportation and, in many cases, complete destruction. We wish them support and the means to find a new normal. The Cancer Center would also like to take this moment to recognize the time, effort and contribution given to this conference by Dr. Erdman. His commitment to cancer research should not be overshadowed by a hurricane, and his leadership in developing this conference is acknowledged. The AICR is hoping to reschedule the conference for Spring 2013. Additional information about the conference can be found here.

JohnErdman

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The University of Illinois Cancer Center would like to congratulate Victor LaGroon, Program Coordinator for the Cancer Center, on his appointment to the City of Chicago Advisory Council on Veterans!  Selected by Mayor Rahm Emanuel, this appointment recognizes Victor’s continued commitment to communities throughout Chicago, and more specifically, the needs of our Veterans.  The Council stands as a liaison between the city government and the Veteran community, addressing program and organizational deficits, and providing support within various social services, civil, and faith-based institutions.  The Council then works to develop manners of cooperation, with regards to information, advocacy, referrals, and conflict management and resolution.  Congratulations Victor on this well-deserved honor, and thank you for your recognition of the needs of our Veterans!  Please click here for more information about the City of Chicago Advisory Council on Veterans.

VictorLaGroon

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“I’m happy to represent the profession…the Institute of Medicine influences the direction of health care in the U.S., and this gives UIC one more voice in making a difference,” stated Dr. Diana Wilkie, Cancer Center member, Professor of Nursing , and Harriet H. Werley Endowed Chair for Nursing Research, on her recent election of membership to the National Academy of Science’s Institute of Medicine! As one of 70 new members, Dr. Wilkie was elected via an elaborate and selective process, which honors those individuals who have greatly contributed to the advancement of medicine, health science, and public health. Her work has addressed end-of-life and palliative care, and health informatics research, more specifically on their correlations to sickle cell disease and cancer, as well as their utilization in clinical practice and education.  In addition to a career that has been consistently funded for 26 years, Dr. Wilkie has developed and utilized emerging technologies and computer applications for navigating pain management care and palliative care education.  Her collaborative work exceeds the boundaries of the University of Illinois system, as her tools are in place globally and used worldwide.  The Cancer Center congratulates Dr. Wilkie and all that she brings to the University of Illinois system and what she will bring to the Institute of Medicine!  

DianaWilkie

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Congratulations to all of our 2012 ACS Grantees!
Basic Science:


Ron Gaba, MD; Cancer Center Member; CTTI Program 
“Effects of Drug Delivery on Tumor Necrosis after Liver Chemoembolization”                                      

 

 

Xialong He, PhD; Cancer Center Member; CTTI Program
“Functional Significance of CDC42 Alternative Splicing in Ovarian Cancer”

 

 

Antonia Kolokythas, DDS
“Improve Detection of Oral Pre-Malignant Lesions in the Head and Neck”

 

 

Brian Murphy, PhD; Cancer Center Member; CTTI Program 
“Use of Marine Bacteria to Overcome Drug Resistant Ovarian Cancer”

 

 

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Vitalyi Senyuk, PhD 
“Role of miR-124 in EV1-mediated Oncogenesis”

 

Miljan Simonovic, PhD 
“Selection and Targeting of Selenocysteine by Human Elongation Factor”

 

 

Andrew Tsung, MD 
“Targeting EGFR in Glioblastoma by Cord Blood Adult Stem Cells”

 

 

Cancer Control and Population Sciences:

 

Xavier Llor, MD, PhD; Cancer Center Member; PHBO Program 
“Chicago Colorectal Cancer Consortium: Colorectal Cancer in African Americans”

 

 

New Grants from the American Cancer Society’s National Research Program:

 

Joanna Burdette, PhD; Cancer Center Member; CTTI Program 
“Akt Transformation of Ovarian and Fallopian Cells”

 

 

 

Jeremy Johnson, PharmD, PhD ; Cancer Center Member; CCP Program
“Prostate Cancer Chemoprevention with Carnosol by Dual Disruption of AR/ER”

 

 

Sua Myong, PhD 
“Single Molecule Investigation of DNA Repair Mechanism in Cancer”

 

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 Special thanks to the Chicago Fire Major League Soccer Team, who paired with the University of Illinois Hospital and Health Sciences System, to honor breast cancer fighters, survivors, caregivers and families in the community, at their October 27, 2012, game against DC United.  In addition to the Fire’s pink uniforms, soccer scarves and spirit flags, the Fire and its community participants created a live human pink ribbon to honor the fight against breast cancer.  Dr. Bryan Becker participated in the honorary coin toss to start the game, and the Fire ended its chilly match with a 1-1 score.  The takeaway, however, was the delight on the faces of the men, women and children who were there to remember and support their loved ones through the breast cancer battle.  Thank you Chicago Fire and Major League Soccer for recognizing the importance of breast cancer and your community members.

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Photos clockwise from top left: Toyota Park’s recognition of Breast Cancer Awareness on the jumbotron; Goalie Sean Johnson’s autographed gloves; The Chicago Fire in their first huddle of the match; Chicago Fire autographed match ball; Awareness lit up the stadium; Dr. Bryan Becker officiates the coin toss; the Human Breast Cancer Ribbon; Team mascot Sparky waves the Breast Cancer Awareness/Chicago Fire Spirit Flag

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NEW FUNDING OPPORTUNITIES:

AACR-Aflac Incorporated Career Development Award for Pediatric Cancer Research
Sponsor:  AACR, Aflac, Inc.

Deadline:  App 11/12/2012

Encouragement and support for junior faculty who are in the first five years of a faculty appointment (at the start of the grant term) to conduct pediatric cancer research and establish successful career paths in this field.  The research proposed for funding may be basic, translational, clinical or epidemiological in nature and must have direct applicability and relevance to pediatric cancer.

 

AACR – National Brain Tumor Society Career Development Award for Translational Brain Tumor Research
Sponsor:  AACR, National Brain Tumor Society

Deadline:  App 11/12/2012

Encouragement and support for junior faculty who are in the first five years of a faculty appointment (at the start of the grant term) to conduct brain tumor research and establish successful career paths in this field.  The research proposed for funding must be translational in nature and have direct applicability and relevance to brain tumors.

 

AACR Dharma Master Jiantai Innovative Grant for Lung Cancer Research
Sponsor: AACR, Dharma Master Jiantai

Deadline: App 11/20/2012

Funding granted to an investigator for an existing project that develops and studies new ideas and approaches that have direct application and relevance to lung cancer.  Following the Grant-in-Aid of Research model, this support supplements existing funding for an investigator conducting a basic or translational research project that will contribute to the acceleration of progress against lung cancer, for the ultimate goal of improving patient care.

 

Advanced Development of Informatics Technology (U24)
Sponsor: NIH, NCI

Deadline: Earliest submission – 1/22/2013

Purpose is to invite Cooperative Agreement (U24) applications for advanced development and enhancement of emerging informatics technologies to improve the acquisition, management, analysis, and dissemination of data and knowledge in cancer research. An emerging informatics technology is defined as one that has passed the initial prototyping and pilot development stage, has demonstrated potential to have a significant and broader impact, has compelling reasons for further improvement and enhancement, and has not been widely adopted in the cancer research field. If successful, these technologies would accelerate research in cancer biology, cancer treatment and diagnosis, cancer prevention, cancer control and epidemiology, and/or cancer health disparities. This FOA is one component of the NCI's Informatics Technology for Cancer Research (ITCR) Initiative whose central mission is to promote research-driven informatics technology development.  Potential applicants who are interested in early-stage development should consult companion FOAs listed on the previous page.  Applications that focus on informatics data processing and analysis or mathematical/statistical modeling alone without informatics technology development are not appropriate for this FOA.

 

Early-Stage Development of Informatics Technology (U01)
Sponsors: NIH, NCI

Deadline: Earliest submission 12/22/2012

Purpose is to invite Cooperative Agreement (U01) applications for the development of enabling informatics technologies to improve the acquisition, management, analysis, and dissemination of data and knowledge in cancer research. As a component of the NCI's Informatics Technology for Cancer Research (ITCR) Initiative, this FOA focuses on early-stage development from prototyping to hardening and adaptation. The central mission of the ITCR is to promote research-driven informatics technology development. In order to be successful, proposed development plans must have a clear rationale on why the proposed technology is needed and how it will benefit the cancer research community. In addition, mechanisms to solicit feedback from users and collaborators throughout the development process should be included. Applications that focus on data processing and analysis or mathematical/statistical modeling alone without new technology development are not appropriate for this FOA.

 

Exploratory/Developmental Bioengineering Research Grants (EBRG) (R21)
Sponsors: NIH; NCI; National Institute of Biomedical Imaging and Bioengineering; National Heart, Lung and Blood Institute; National Institute on Alcohol Abuse and Alcoholism; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Dental and Craniofacial Research; National Institute on Drug Abuse; National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; Office of Research on Women’s Health

Deadline: 1/16/2013

Purpose is to establish the feasibility of technologies, techniques or methods that: 1) explore a unique multidisciplinary approach to a biomedical challenge; 2) are high-risk but have a considerable pay-off; and 3) develop data which can lead to significant future research. An EBRG application may propose hypothesis-driven, discovery-driven, developmental, or design-directed research and is appropriate for evaluating unproven approaches for which there is minimal or no preliminary data.

 

Effects of In Utero Alcohol Exposure on Adult Health and Disease (R01)
Sponsor: NIU, National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Deadline:  Earliest submission – 1/5/2013

Intended for support of novel research on how prenatal alcohol exposure may contribute to the tiology of chronic diseases and health conditions later in life.  Central to this theme is the developmental origins of health and disease (DOHaD) concept, which suggests that fetal adaptations in response to adverse intrauterine conditions may increase the risk for childhood and adult disease.  The foald of this FOA is to stimulate a broad range of research to: 1)leverage existing prospective birth cohorts to define the role fo maternal alcohol consumption in the DOHaD process; 2) investigate the biological, cellular and molecular mechanisms by which prenatal alcohol exposure may impact disease outcomes later in life; and 3) identify biomarkers associated with gestational alcohol exposure that may predict adult disease susceptibility in exposed offspring.  Studies supported by this FOA will provide fundamental insights into a possible fetal-basis to adult disease that is influenced by maternal alcohol use.

 

Effects of In Utero Alcohol Exposure on Adult Health and Disease (R21)
Sponsor: NIU, National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Deadline:  Earliest submission – 1/16/2013

Intended for support of novel research on how prenatal alcohol exposure may contribute to the tiology of chronic diseases and health conditions later in life.  Central to this theme is the developmental origins of health and disease (DOHaD) concept, which suggests that fetal adaptations in response to adverse intrauterine conditions may increase the risk for childhood and adult disease.  The foald of this FOA is to stimulate a broad range of research to: 1)leverage existing prospective birth cohorts to define the role fo maternal alcohol consumption in the DOHaD process; 2) investigate the biological, cellular and molecular mechanisms by which prenatal alcohol exposure may impact disease outcomes later in life; and 3) identify biomarkers associated with gestational alcohol exposure that may predict adult disease susceptibility in exposed offspring.  Studies supported by this FOA will provide fundamental insights into a possible fetal-basis to adult disease that is influenced by maternal alcohol use.

 

Examination of Survivorship Care Planning Efficacy and Impact (R21)
Sponsors: NIH, NCI

Deadline:  Earliest submission – 1/5/2013

Purpose is to stimulate research to evaluate the effect of care planning on cancer survivors' health and psychosocial outcomes; self-management of late effects and adherence to cancer screening and health behavior guidelines; utilization of follow-up care; organizational-level factors influencing the implementation of care planning; and associated costs. Specifically, the FOA aims to stimulate research that will: 1) develop and test metrics for evaluating the impact of survivorship care planning; 2) evaluate the impact of survivorship care planning on cancer survivors' morbidity, self-management and adherence to care recommendations, utilization of follow-up care, and on systems outcomes, such as associated costs and impact on organizations implementing care planning; and 3) identify models and processes of care that promote effective survivorship care planning. The ultimate goal of this FOA is to generate a body of science that will inform the development and delivery of interventions and best practices in follow-up care for cancer survivors. 

 

Examination of Survivorship Care Planning Efficacy and Impact (R01)
Sponsors: NIH, NCI

Deadline:  Earliest submission – 1/5/2013

Purpose is to stimulate research to evaluate the effect of care planning on cancer survivors' health and psychosocial outcomes; self-management of late effects and adherence to cancer screening and health behavior guidelines; utilization of follow-up care; organizational-level factors influencing the implementation of care planning; and associated costs. Specifically, the FOA aims to stimulate research that will: 1) develop and test metrics for evaluating the impact of survivorship care planning; 2) evaluate the impact of survivorship care planning on cancer survivors' morbidity, self-management and adherence to care recommendations, utilization of follow-up care, and on systems outcomes, such as associated costs and impact on organizations implementing care planning; and 3) identify models and processes of care that promote effective survivorship care planning. The ultimate goal of this FOA is to generate a body of science that will inform the development and delivery of interventions and best practices in follow-up care for cancer survivors.

 

Landon Foundation – AACR INNOVATOR Award for Cancer Prevention Research
Sponsor: Landon Foundation, AACR

Deadline:  App 11/20

The Landon Foundation – AACR INNOVATOR Award for Cancer Prevention Research was established to recognize the outstanding achievement of a junior faculty-level scientist working in the field of cancer prevention, and support his or her novel and innovative research that, if successful, will have strong potential for high impact in the cancer prevention field.

 

Revisions for Early-Stage Development of Informatics Technology (R01)
Sponsor: NIH, NCI

Deadline: Earliest submission – 12/22/1012

Purpose is to is to encourage revision applications (formerly called "competing revisions") from currently funded NCI R01 and R37 (MERIT) research projects for early-stage development of enabling informatics technologies to improve the acquisition, management, analysis, and dissemination of data and knowledge. As a component of the NCI's Informatics Technology for Cancer Research (ITCR) Initiative, this FOA aims to promote interdisciplinary collaboration in the development of innovative computational methods and informatics approaches that are essential for cancer research on all fronts to accelerate scientific discovery and ultimately translate data into knowledge and clinical practice. Applications that focus on data processing and analysis or mathematical/statistical modeling alone without new technology development are not appropriate for this FOA.

 

Revisions for Early-Stage Development of Informatics Technology (U01)
Sponsors: NIH, NCI

Deadline: Earlist submission 12/22/2012

Purpose is to invite revisions (formerly called "competing revisions") from currently funded NCI U01 cooperative agreement projects for early-stage development of enabling informatics technologies to improve the acquisition, management, analysis, and dissemination of data and knowledge. As a component of the NCI's Informatics Technology for Cancer Research (ITCR) Initiative, this FOA aims to promote interdisciplinary collaboration in the development of innovative computational methods and informatics approaches that are essential for cancer research on all fronts to accelerate scientific discovery and ultimately translate data into knowledge and clinical practice. Applications that focus on data processing and analysis or mathematical/statistical modeling alone without new technology development are not appropriate for this FOA.

 

Revisions for Early-Stage Development of Informatics Technology (P01)
Sponsors: NIH, NCI

Deadline: Earliest submission 1/22/2013

Purpose is to invite revisions (formerly called "competing revisions") from currently funded NCI P01 program projects for early-stage development of enabling informatics technologies to improve the acquisition, management, analysis, and dissemination of data and knowledge. As a component of the NCI's Informatics Technology for Cancer Research (ITCR) Initiative, this FOA aims to promote interdisciplinary collaboration in the development of innovative computational methods and informatics approaches that are essential for cancer research on all fronts to accelerate scientific discovery and ultimately translate data into knowledge and clinical practice. Applications that focus on data processing and analysis or mathematical/statistical modeling alone without new technology development are not appropriate for this FOA. 

 

Specialized Programs of Research Excellence (SPORESs) in Human Cancer for Years 2012 and 2014 (P50)
Sponsors: NIH, NCI, National Institute of Dental and Craniofacial Research (NIDCR)
National Institute of Neurological Disorders and Stroke (NINDS)

Deadline:   1/24/2013; 9/3/2014

Program will fund 5-year P50 SPORE grants to support state-of-the-art investigator-initiated translational research that will contribute to improved prevention, early detection, diagnosis, and treatment of an organ-specific cancer (or a related group of cancers).  SPOREs are expected not only to conduct a wide spectrum of research activities, but also to contribute significantly to the development of specialized shared resource core facilities (cores), improved research model systems, and collaborative research projects with other institutions. The research supported through this program must be translational in nature and must always be focused upon knowledge of human biology stemming from research using cellular, molecular, structural, biochemical, and/or genetic experimental approaches with the goal of a translational human endpoint within the 5 year term of the grant. In addition, SPOREs must include both a Developmental Research Program for pilot studies and a Career Development Program to foster careers in organ-based translational science.

 



 

 


In this issue

 

upcoming events

 

Recent Publications

  funding opportunities

 

 


Click here for new
Funding Opportunities.

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UPCOMING CANCER CENTER EVENTS

IHRP Distinguished Lecture:

“Childhood Roots of Disparities in Cardiovascular Disease in Adulthood: A Multidisciplinary Perspective”

        11/7, 11:00 AM – 12:00 PM

SPH Auditorium

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Celebrando la Mujer Latina: Uniting Generations for a Healthy Future

11/10, 8:00 AM

Student Center West

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Advances in Myeloproliferative Neoplasms Workshop

November 16, 2012; 2:00 -6:00 pm

COMRB, Moss Auditorium

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COM Research Forum and Prize Competition

11/16, 9:00 AM – 4:00 PM

Student Center West

2nd Floor Conference Room

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Bridging the Gap: Emerging Health Issues in Underrepresented Minorities

    November 17, 2012;  8:30 AM – 3:00 PM

UIC Forum

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RECENT PUBLICATIONS

Damaged DNA Binding Protein 2 in Reactive Oxygen Species (ROS) Regulation and Premature Senescence

Bagchi S, Raychaudhuri P, et al

Design of T-cell receptor libraries with diverse binding properties to examine adoptive T-cell responses

Kranz DM, et al

MMP-9 and uPAR regulated glioma cell migration

Rao JS, et al

Racial/Ethnic Differences in Dietary Intake among WIC Families Prior to Food Package Revisions

Berbaum M, Fitzgibbon ML, Odoms-Young AM, et al

ResearchTracking: Monitoring Gender and Ethnic Minority Recruitment and Retention in Cancer Symptom Studies

Wilkie DJ, et al

Soft fibrin gels promote selection and growth of tumorigenic cells
           Wang N, et al

Targeting FOXM1 in cancer

Gartel AL, et al

Tumor regression by phenethyl isothiocyanate involves DDB2

Bagchi S, Raychaudhuri P, et al

 

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