JANUARY 2014

university of illinois CANCER CENTER
UPDATE

Becknma

Congratulations to PHBO members Carl Asche, PhD, Research Professor and Director, Center for Outcomes Research, College of Medicine in Peoria, and Jinma Ren, PhD, Research Specialist, Center for Outcomes Research, College of Medicine in Peoria, and their team, on their recently received  American Cancer Society grant titled “Family, Nutrition, Physical Activity (FNPA) Tool: A Motivational Interviewing-based Practice Intervention to Address Pediatric Health Behaviors Practice Intervention,” which was featured on the Peoria affiliate of CBS News and CINewsNow.com.

Sources: "UICOMP Receives $250,000 to Fight Childhood Obesity." CentralIllinoisProud.com. Nexstar Broadcasting Inc., 3 Jan. 2014. Web. 10 Jan. 2014. <http://www.centralillinoisproud.com/story/uicomp-receives-250000-to-fight-childhood-obesity/d/story/8Ermtqn85UWWibOuytmf_g>.
"Grant Helps Local Researchers in the Fight against Childhood Obesity." CINewsNow. Granite Broadcasting Stations, 2 Jan. 2014. Web. 10 Jan. 2014. <http://www.cinewsnow.com/home/Grant-helps-local-researchers-in-the-fight-against-childhood-obesity-238520411.html>.

 

Asche
 
Jinma
Dr. Carl Asche
Dr. Jinma Ren

 

Congratulations to CCP member Joel Schwartz, PhD, Professor, Department of Oral Medicine and Diagnostic Sciences, College of Dentistry, with colleague Dr. Guy Adami, on receiving a two-year NCI grant for $160,000 for their research titled “Green tea effects on gene expression in tobacco users.” One of the primary attributes of their research is that the sampling is pain free and does not require a biopsy, with the intent to determine how green tea can prevent smoking-related oral cancers.  Drs. Adami and Schwartz also received a National Science Foundation grant for their research titled “A noninvasive gene expression based classifier for oral cancer.”  The NSF grant is a Small Business Technology Transfer Grant, focusing on oral cancer screening technologies, with larger implications to make screenings noninvasive and more accurate.  

Sources:  Bike, William. "Drs. Adami & Schwartz Awarded NCI Grant to Study “Green Tea Effects on Gene Expression in Tobacco Users” Posted on 12/24/2013." UIC College of Dentistry. The Board of Trustees of the University of Illinois, 24 Dec. 2013. Web. 8 Jan. 2014.
"Drs. Adami and Schwartz Awarded National Science Foundation Grant for “A Noninvasive Gene Expression Based Classifier for Oral Cancer." UIC College of Dentistry. The Board of Trustees of the University of Illinois, 6 Jan. 2014. Web. 8 Jan. 2014.

 

Congratulations to CTT member Rashid Bashir, PhD, Bliss Professor, Bliss Professor of Engineering, Head of the Department of Bioengineering, and Co-Director of the Center for Nanoscale Science and Technology on the Urbana campus, whose 2nd generation microfluidic biochip research was published in Science Translational Medicine. In its current model, Dr. Bashir’s concept is similar to that of a blood glucose monitoring tool, and is used to quickly and accurately count white blood cells that are sensitive to the HIV virus, making an HIV diagnosis easily attainable. This is of particular value in rural areas and countries where large populations of people might be living with HIV/AIDS and not have the proper tools to test and, therefore, be treated. Looking towards the future of microfluidic biochipping, Dr. Bashir sees implications in other areas of medicine, particularly cancer, where a patient’s CBC could be self-obtained on chip, analyzed in a much shorter period of time and submitted electronically to a physician.   Bashir’s original HIV biochip is intended for commercial distribution within the next year, and hopefully the 2nd generation isn’t far behind.

Sources: Des Garennes, Christine. "Device Developed at UI Could Make HIV Testing Easier, Faster."News-Gazette.com. News-Gazette, 10 Dec. 2013. Web. 9 Jan. 2014.

Bashir, Rashid. "Microfluidic Biochip." 8 Jan. 2014. E-mail.

Schwartz
 
Bashir
Dr. Joel Schwartz
 
Dr. Rashid Bashir

 

 

Congratulations to CB member Maxim Frolov, PhD, Associate Professor, Biochemistry and Molecular Genetics, College of Medicine, on his research that was published in Developmental Cell and featured in the American Association of Cancer Institutions Update, investigating the role of mitochondria in “radiation resistant cancer.” Dr. Frolov and co-author, CB member Elizaveta Benevolenskaya, PhD, Associate Professor, Biochemistry and Molecular Genetics, College of Medicine, looked at the apoptosis process as instigated by radiation and how mitochondria factors into it.  When exploring the E2F gene as part of apoptosis, Frolov, Benevolenskaya and team developed an E2F mutated version, which in turn caused the  mitochondria to become misshapen.  In its misshapen form, it was unable to produce energy and therefore became resistant to radiation.  When attempted on human cells, it responded similarly. The long term implications can help recognize why some cancers are more receptive to radiation, as well as enable the development of therapies targeted to altering the mitochondrial function, which would in turn make radiation more effective.

Source: Parmet, Sharon. "Dysfunctional Mitochondria Mnay Underlie Resistance to Radiation Therapy." UIC News Center. The Board of Trustees of the University of Illinois, 25 Nov. 2013. Web. 9 Jan. 2014.


Congratulations to CTT member Michael Spiotto, MD, PhD, Lecturer, Radiation Oncology, PHBO member Antonia Kolokythas, DDS, Associate Professor, Oral and Maxillofacial Surgery, College of Dentistry, and Drs. Mark Ranck, Rainier Abundo, Gina Jefferson, Barry Wenig, and Ralph Weichselbaum, on the publication of their study in JAMA Otolaryngology – Head & Neck Surgery.  Titled “Postradiotherapy Neck Dissection Improves Local Control in Head and Neck Squamous Cell Carcinoma Patients With Advanced Nodal Disease,” their research was a retroactive study, conducted entirely at the UIC campus, from January 1, 2000, until December 31, 2012, investigating 287 head and neck cancer patients.  Specifically, the team investigated those who had been diagnosed with stage III/IV disease, treated with radiation therapy, either with or without postradiotherapy neck dissection, and then to determine the benefit of postradiotherapy neck dissection as manner of control in advanced nodal disease.  The results proved to be beneficial in advanced nodal disease, but not statistically significant with less-advanced and/or distant metastases.

Sources: Stenger, Matthew. "Postradiotherapy Neck Dissection Improves Local Control in Head and Neck Squamous Cell Carcinoma Patients With Advanced Nodal Disease." The ASCO Post (2013): n. pag. 3 Dec. 2013. Web. 9 Jan. 2014. < http://ascopost.com/ViewNews.aspx?nid=10798>

Ranck, Mark C., MD, Ranier Abundo, BA, Gina Jefferson, MD, Antonia Kolokythoas, DDS, Barry L. Wenig, MD, Ralph R. Weichselbaum, MD, and Michael T. Spiotto, MD, PHD. "Effect of Postradiotherapy Neck Dissection on Nonregional Disease Sites." JAMA Otolaryngology - Head & Neck Surgery (2013): n. pag. 21 Nov. 2013. Web. 9 Jan. 2014.

 

Congratulations to Dr. Kolokythas, who has also recently authored and edited the book Lip Cancer: Treatment and Reconstruction, published by Springer.  Co-authors with Kolokythas were CTT members Michael Spiotto, MD, PhD; Lucy Chen, MD; and UIC faculty Thomas Schlieve, DDS, MD;  Abhishek Solanki, MD; Andrew Howard, MD, and Gowri Ramadas, MD.  The text provides a comprehensive guide to the anatomy, treatment and management of lip cancer, as well as reconstruction in the context of the aesthetics and function of the lips.  Lip Cancer: Treatment and Reconstruction can be found on Amazon.com and through other booksellers.  It can be found at ISBN #978-3642381799 in hardcover.

Sources: Kolokythas, Antonia. "Cancer Center News." 10 Jan. 2014. E-mail.

"Lip Cancer: Treatment and Reconstruction." Amazon. Amazon.com Inc., 7 Nov. 2013. Web. 10 Jan. 2013. <http://www.amazon.com/Lip-Cancer-Reconstruction-Antonia-Kolokythas/dp/3642381790/ref=sr_1_1_bnp_1_har?ie=UTF8&qid=1389385666&sr=8-1&keywords=lip+cancer%3A+treatment+and+reconstruction>.

 

Maxim

Spiotto

Kolokythas

 

Chen

 

Dr. Maxim Frolov
Dr. Michael Spiotto
Dr. Antonio Kolokythas
Dr. Lucy Chen

 

AROUND THE CANCER WORLD

Research Presented at the San Antonio Breast Cancer Symposium

Additional Cancer News

Baylor University Medical Center

City of Hope

Columbia University (w/ Tel Aviv University)

Dana-Farber Cancer Institute

Dartmouth-Hitchcock Norris Cotton Cancer Center

Duke University

Emory University

Harvard University

Indiana University

Johns Hopkins

Mayo Clinic

MD Anderson

MIT

New York University Langone Medical Center

Northwestern University

The Ohio State University

Oregon Health and Science University

Purdue University

Rutgers/Cancer Institute of New Jersey

Roswell Park Cancer Institute

Rutgers/Cancer Institute of New Jersey

Stanford University

St. Jude’s Children’s Research Hospital

Temple University Fox Chase Cancer Center

Thomas Jefferson University

University Hospitals Case Medical Center

University of Alabama at Birmingham

University of California, Davis

University of California, Los Angeles

University of California, San Diego

University of Chicago

University of Colorado Cancer Center

University of Iowa

University of Michigan

University of New Mexico

University of North Carolina

University of Pennsylvania

University of South Carolina

University of South Florida

University of Southern California

UT Southwestern

University of Utah Huntsman Cancer Center

University of Washington Fred Hutchison Cancer Research Center

Vanderbilt University

Virginia Commonwealth University Massey Cancer Center

Washington University

 

SEEKING APPLICANTS

Hematology Summer Research Opportunity for Med Students
Sponsor:  American Society of Hematology (ASH™) Minority Medical Student Award Program
Deadline: March 10, 2014
“This award program provides funding to medical students to allow them to complete a summer research experience and to attend the ASH annual meeting. The MMSAP is an eight- to-twelve-week summer research experience for minority students in their first or second years of medical school…The goal of the partnership is to increase the number of underrepresented minority scholars from the field of hematology with academic and research appointments.  The MMSAP serves as a stepping stone towards achieving this goal by giving students the opportunity to have hematology research experience.” Contact Mary Lou Schmidt with questions – 6-6413

Source: Gebremedhin, Meley. "AHS Med Student Summer Announcement." Letter to Training Program Director. 9 Oct. 2013. American Society of Hematology Minority Medical Student Award Program, 1 Nov. 2013. Web. 1 Nov. 2013

 

 

 

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In this issue

 

Cancer Center News

upcoming events

Recent Publications

AROUND THE CANCER WORLD

 

 

 

 

 

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UPCOMING

CANCER CENTER EVENTS

 

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Ethical Issues in Informed Consent in Community-Based Research – Panel Discussion


Tuesday, January 21, 2013; 11:30 am – 1:00 pm Westside Research Office Building, 1747 W. Roosevelt Rd., Rm. 461

Led by: Emily Anderson, PhD, MPH, Assistant Professor of Bioethics, Neiswanger Institute for Bioethics, Loyola University Stritch School of Medicine

Panelists:
Kathi Diviak, PhD, Research Scientist, UIC Institute for Health Research and Policy

Charles Hoehne, PhD, Assistant Director of Education and Training, UIC Office for the Protection of Research Subjects

Angela Odoms-Young, PhD, Assistant Professor of Kinesiology and Nutrition

Lynn Podraza, MS, Coordinator, Regulatory Knowledge and Support, UIC Center for Clinical and Translational Science

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UIC School of Public Health and Office of Research Service
SPH ORS Grant Workshop: How to Find and Review Funding Opportunities


Thursday, January 23, 2014; 10:00 am – 12:00 pm; SPH-PI, 1603 W. Taylor St., Room 1136

Featuring Julie Kong, Med, RD, LDN, CRA, Director of Research Services

Contact Julie Kong at jckong@uic.edu; Register online.

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Cancer Biology Program Seminar

Tuesday, January 28, 2014; 12:00 pm; MBRB, 900 S. Ashland Ave., Rm. 1152

Featuring  Barbara Jung, MD, Associate Professor of Medicine; Chief, Division of Gastroenterology and Hepatology, UIC

 “Activin signaling in colon cancer”

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IHRP Brown Bag Lecture: Lessons Leared from a Community-based Weight Loss Program for African American Women

Wednesday, January 29, 2013; 12:00 - 1:00 pm Westside Research Office Building, 1747 W. Roosevelt Rd., Rm. 561

Featuring Angela Odoms-Young, PhD, Assistant Professor of Kinesiology and Nutrition

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Cancer Center PHBO Program Lecture
Thursday, February 6, 2014; 12:00 pm;  Westside Research Office Building, 1747 W. Roosevelt Rd., Rm. 561

Featuring Garth H. Rauscher, PhD; Associate Professor, Department of Epidemiology, School of Public Health

“Colon Cancer Patterns of Care in Chicago: Provocative findings and a discussion of future research opportunities and directions

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Cancer Center CCP Program Lecture
Thursday, February 13, 2014; 12:00 pm
COMRB, 909 S. Wolcott St., Rm 7175

Featuring Djaja Soejarto, PhD, Professor of Pharmacognosy, Department of Medicinal Chemistry and Pharmacognosy

"Anticancer agents from plants: Is there a Collection Approach that gives highest probability of discovery?"

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2013 CCSW Woman of Year Reception for

Judy L. Bolton, PhD

Tuesday, February 25, 2014; 11:30 am – 1:30 pm; Student Center West, Thompson Rooms A and B

The event will honor Judy L. Bolton, PhD, full Professor and Head of the Department of Medicinal Chemistry and Pharmacognosy.  “This annual award honors a UIC woman who has consistently worked on women’s issues beyond the call of duty and who is an exemplary role model.”  Congratulations to Dr. Bolton!

 

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RECENT PUBLICATIONS

 

A comparison of alternative methods for measuring cigarette prices.   

Chaloupka FJ, Tauras JA, Strasser JH, Willis G, Gibson JT, Hartman AM

 

Advance care treatment plan ACT-Plan for African American family caregivers: A pilot study.

Bonner GJ, Wang E, Wilkie DJ, Ferrans C,Dancy B, Watkins Y.

 

Assessment of clinical and nonclinical characteristics associated with health-related quality of life in patients with high-grade gliomas: a feasibility study.         

Porter KR, Menon U, Vick NA, Berbaum ML, Davis FG.

 

Blood methylomics in response to arsenic exposure in a low-exposed US population.


Liu X, Zheng Y, Zhang W, Zhang X, Lloyd-Jones DM, Baccarelli AA, Ning H, Fornage M, He K, Hou L.

 

BMPR1A mutations in early-onset colorectal cancer with mismatch repair proficiency.


Fernandez-Rozadilla C, Brea-Fernández A, Bessa X, Alvarez-Urturi C, Albulí A, Clofent J, Payá A, EPICOLON Consortium, Jover R, Llor X, Andreu M, Castells A, Carracedo A, Castellví-Bel S, Ruiz-Ponte C.

 

Conference report on tobacco taxes in central America: current situation and opportunities to reduce prevalence and increase fiscal revenues.
               

Garcés A, Garcés M, Barnova J, Cabrera M, Sandoval R, Orozco JG, Chaloupka FJ.

 

Differential effects of epigenetic modifiers on the expansion and maintenance of human cord blood stem/progenitor cells.
               

Mahmud N, Petro B, Baluchamy S, Li X, Taioli S, Lavelle D, Quigley J, Suphangul M, Araki H.

 

Digital Detection for Tobacco Control: Online Reactions to the United States’ 2009 Cigarette Excise Tax Increase.
           Ayers JW, Althouse BM, Ribisi KM, Emery S.

 

Estradiol increases ER-negative breast cancer metastasis in an experimental model.

Yang X, Belosay A, Du M, Fan TM, Turner RT, Iwaniec UT, Helferich WG.

 

Fit and Strong! Plus: Design of a comparative effectiveness evaluation of a weight management program for older adults with osteoarthritis.

Smith-Ray RL, Fitzgibbon ML, Tussing-Humphreys L, Schiffer L, Shah A, Huber GM, Braunschweig C, Campbell RT, Hughes SL.

 

hnRNP C1/C2 and Pur-beta proteins mediate induction of senescence by oligonucleotides homologous to the telomere overhang.

Mulnix RE, Pitman RT, Retzer A, Bertram C, Arasi K, Crees Z, Girard J, Uppada SB, Stone AL, Puri N.

 

Impact of alternative approaches to assess outlying and influential observations on health care costs.

Weichle T, Hynes DM, Durazo-Arvizu R, Tarlov E, Zhang Q.

 

Knockdown of cathespin B and uPAR inhibits CD151 abd α3β1 integrin-mediated cell adhesion and invasion in glioma.

Rao Malla R, Gopinath S, Alapati K, Gorantia B, Gondi CS, Rao JS.

 

Leverage Hadoop Framework for Large Scale Clinical Informative Applications.

Dong X, Bahroos N, Sadhu E, Jackson T, Chukhman M, Johnson R, Boyd A, Hynes D.

 

MicroRNA-99 Family Members Suppress Homeobox A1  Expression in Epithelial Cells.

Chen D, Chen Z, Jin Y, Dragas D, Zhang L, Adjei BS, Wang A, Dai Y, Zhou X.

 

MYC-driven accumulation of 2-hydroxygluterate is associated with breast cancer prognosis.

Terunuma A, Putluri N, Mishra P, Mathé EA, Dorsey TH, Yi M, Wallace TA, Issaq HJ, Zhou M, Killian JK, Stevenson HS, Karoly ED, Chan K, Samanta S, Prieto D, Hsu TY, Kurley SJ, Putluri V, Sonavane R, Edelman DC, Wulff J, Starks AM, Yang Y, Kittles RA, Yfantis HG, Lee DH, Ioffe OB, Schiff R, Stephens RM, Meltzer PS, Veenstra TD, Westbrook TF, Sreekumar A, Ambs S

Nicotine and tobacco research special supplement: economic aspects of tobacco use in low-and middle-income countries.

Kostova D, Chaloupka FJ, Yurekli A, Bettcher D, Prasad N, Asma S.

 

Optimization of Methyl Jasmonate Application of Broccoli Florets to Enhance Health-promoting Phytochemical Content.
                Ku KM, Jeffrey EH, Juvik JA.

 

Pharmacogenomics in colorectal cancer: a genome-wide association study to predict toxicity after 5-fluorouracil or FOLFOX administration.

Fernandez-Rozadilla C, Cazier JB, Moreno V, Crous-Bou M, Guinó E, Durán G, Lamas MJ, López R, Candamio S, Gallardo E, Paré L, Baiget M, Páez D, López-Fernández LA, Cortejoso L, García MI, Bujanda L, González D, Gonzalo V, Rodrigo L, Reñé JM, Jover R, Brea-Fernández A, Andreu M, Bessa X, Llor X, Xicola R, Palles C, Tomlinson I, Castellví-Bel S, Castells A, Ruiz-Ponte C, Carracedo A; EPICOLON Consortium.

 

Policy, systems, and environmental approaches for obesity prevention: a framework to inform local and state action.

Lyn R, Aytur S, Davis TA, Eyler AA, Evenson KR, Chriqui JF, Cradock AL, Goins KV, Brownson RC.

 

Results from a community-based smoking cessation treatment program for LGBT smokers.

Matthews AK, Li CC, Kuhns LM, Tasker TB, Cesario JA.

 

Roles and strategies of state organizations related to school-based physical education and physical activity policies.

Cradock AL, Barrett JL, Carnoske C, Chriqui JF, Evenson KR, Gustat J, Healy JB, Heinrich KM, Lemon SC, Tompkins NO, Reed HL, Zieff SG.

 

Ruminal epithelium transcriptome dynamics in response to plane of nutrition and age in young Holstein calves.

Naeem A, Drackley JK, Lanier JS, Everts RE, Rodriguez-Zas SL, Loor JJ.

 

Selective modulation of endoplasmic reticulum stress markers in prostate cancer cells by a standardized mangosteen fruit extract.

Li G, Petiwala SM, Pierce DR, Nonn L, Johnson JJ.

 

Smoking and prostate cancer in a multi-ethnic cohort.

Murphy AB, Akereyeni F, Nyame YA, Guy MC, Martin IK, Hollowell CM, Walker K, Kittles RA, Ahaghotu C.

 

State and district policy influences on district-wide elementary and middle school physical education practices.
             Chriqui JF, Eyler A, Carnoske C, Slater S.

 

Stem cell expansion during  carcinogenesis in stem cell-depleted conditional telomeric repeat factor 2 null mutant mice.
              Bojovic B, Ho HY, Wu J, Crowe DL.

 

Weight loss maintenance in African American women: a systematic review of the behavioral lifestyle intervention literature.

Tussing-Humphreys LM, Fitzgibbon ML, Kong A, Odoms-Young A.

 

Who quits? An overview of quitters in low-and middle-income countries.
            Shang C, Chaloupka F, Kostova D.

 

CTT member Larry Schook, PhD, Professor of Agriculture, Consumer and Environmental Sciences and Vice President for Research, was quoted in the article UIC Approves $5 Million Matching Grant for New Illinois Manufacturing Lab.

Source: "UIC Approves $5 Million Matching Grant for New Illinois Manufacturing Lab."Thechicagocitizen.com. The Chicago Citizen, 2 Jan. 2014. Web. 8 Jan. 2014.

 

CB member Robert Winn, MD, Associate Vice President for Community-Based Practice, was quoted in the article “UI Health opens new Mile Square Health Center.”

Source: Parmet, Sharon. "UI Health Opens New Mile Square Health Center." UIC News Bureau. The Board of Trustees of the University of Illinois, 2 Jan. 2014. Web. 8 Jan. 2014. <http://news.uic.edu/ui-health-opens-new-mile-square-health-center>.

 

 

 

 

 

 

 

 

 

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