october 3, 2013

university of illinois CANCER CENTER



As of publication, we are still amidst a governmental shutdown. The National Institutes of Health and the National Cancer Institute have posted the most updated recommendations for continuing research in an uncertain climate.  Because all communication with these agencies has been halted, it has been recommended that any new funding applications be placed on hold until further notification from these agencies.  The Cancer Center will continue to update you as new information becomes available.

The Cancer Center welcomes…

Akil Maheshwari, MD; Associate Professor of Pediatrics; Chief of Neonatology; Department of Pediatrics in the College of Medicine. Dr. Maheshwari has joined the Cancer Targets and Therapeutics Program.

Ramasamy Jagadeeswaran, PhD; Research Assistant Professor; Department of Pediatrics, in the College of Medicine. Dr. Jagadeeswaran has joined the Cancer Targets and Therapeutics Program.

Venkata Ramesh Dasari, PhD; Research Assistant Professor, Department of Cancer Biology and Pharmacology, in the College of Medicine, Peoria.  Dr. Dasari has joined the Cancer Biology Program.

Irum Khan, MD; Assistant Professor of Medicine, Section of Hematology/Oncology, in the College of Medicine.  Dr. Khan has joined the Cancer Targets and Therapeutics Program.

Edith Nutescu, PharmD, FCCP, MS CTS; Clinical Professor, Department of Pharmacy Practice & Center for Pharmacoeconomic Research. Dr. Nutescu has joined the Cancer Targets and Therapeutics Program.

Changwon Park, PhD, MS; Assistant Professor, Department of Pharmacology, College of Medicine.  Dr. Park has joined the Cancer Biology Program.

Akhil   Dasari   IrumKhan   Nutescu   changwon
Dr. Akil Maheshwari
Dr. Venkata Ramesh Dasari
Dr. Irum Khan
Dr. Edith Nutescu
Dr. Changwon Park

**Not pictured: Dr. Ramasamy Jagadeeswaran


Congratulations to… Dr. Damiano Rondelli, his team, and the Binaytara Foundation, who received ASCO endorsement on their recent BAM 2013: International Conference on Advances in Hematologic Malignancies, held September 13 and 14 in Kathmandu, Nepal!  ASCO is highly selective in their conference endorsement, and receiving it will enable greater opportunities for educational grants from pharmaceutical companies and other potential funding sources, as well as support UIC and the Binaytara Foundation’s training initiatives.  ASCO endorsement is shown towards the bottom of the conference website and on the ASCO calendar.



The Cancer Center’s Clinical Trials Office held its’ 2nd Annual Fall Kickoff on September 26, 2013.  The event recognized all of the physicians, nurses, staff and administration that enable the success of our clinical trials and a glimpse at the future direction our trials will take, with the induction of phase 1 trials.  Each month brings additional accruals to our clinical trials, and more treatment opportunities to patients that might not otherwise have such options.  Thank you for your continued support of the Clinical Trials office, and we are looking forward to our continued growth!

Gals   listening   ozer

From left: Regina Schwind, Associate Director of Administration for the Cancer Center; Joanna Hill, Administrative Director for Clinical Trials; Meha Singh, MS, PMRC/DSMC Director

  Clinical Trials clinicials and administrative staff listening to patient testimonials.   Dr. Howard Ozer, Director of the Cancer Center addressing the attendees about the importance of clinical trials within the scope of cancer treatment.


Student Center West hosted the Health Science Enterprise Town Hall Meeting on October 1, 2013.  A packed room of physicians, nurses, administration, faculty and staff had the opportunity to learn about the changing dynamics of the Health Sciences System and its relationship within the context of UIC and the greater scope of the University of Illinois. After an introduction by University of Illinois President, Robert Easter, and UIC Chancellor and John Corbally Presidential Professor, Paula Allen-Meares, the committee presented a variety of options of which to construct a new path.  With a goal to create stakeholders and provide the community with an opportunity to ask questions and have their voices heard, the most viable options were presented, with the conceit that a decision will not be made too soon.

For a leadership structure, the primary foundation would be an integration of the Health Sciences Colleges with either the Vice President of Health Affairs or the Vice Chancellor of Health Affairs, and subsequent reporting of Deans to the Vice President or the Vice Chancellor, respectively. As well, this would create a “virtual” health sciences campus and create greater alignment between the colleges and respective clinical practice. Either option will require significant board restructuring, budget reallocation, and leadership shifts and education to cover a broader scope of administration.  As well, there is a need for an identity and the establishment of a brand, be it a single brand or a “house of brands.” (Ziskind, 2013) 

Questions ranged from the concerns of funding and creating a physical property that can remain competitive in the current regional healthcare market, to fears that a “virtual” health sciences campus will alienate basic sciences, behavioral sciences, applied health sciences and social work, which reside elsewhere on campus and do not maintain the same access to the physical facilities on West campus.  Also addressed were the larger and currently un-resolved issues of identity, branding and a determination of a regional University of Illinois versus a state system of the University of Illinois.  The concluding remark came from Professor and Head of the Department of Medicine, Dr. Patricia Finn, who requested that all options continue to be considered, and that decisions are made with the institutional mission in mind, in the day-to-day achievement of that mission, the manner in which it is reflected in leadership, and the integration of this mission with the research, care and education that are integral to the University of Illinois.

Source: Ziskind, Andrew, MD. Health Enterprise Town Hall Meeting. Student Center West, Chicago. 1 Oct. 2013.


Imerman Angels Tuxes and Tees Ball


With over 500 people in attendance, Imerman Angels 1-on-1 Cancer Support hosted its first ever Tuxes and Tees Ball, on Saturday, September 28, raising financial support and awareness for its massive national and international network. Founded by two-time testicular cancer survivor, Jonny Imerman, Imerman Angels is a grassroots organization that provides free, mentored support to any cancer fighter, survivor or caregiver, worldwide.  The organization connects individuals with those that have the most similar diagnosis and life circumstances. Based in Chicago, Imerman Angels is represented in over 60 countries and has matched over 9,000 individuals.  Dr. Ozer serves on the Imerman Angels Medical Advisory Board, and Dawn Smith served for two years on the Imerman Angels Professionals Board and continues to volunteer.



Postdoctoral position available immediately to study the APE1/Ref-1 gene/protein in pancreatic, leukemia and/or cancer induced peripheral neuropathy (CIPN). We are looking for a recent Ph.D. graduate with experience in confocal microscopy, tissue culture, cell and molecular biology including EMSA, immunoprecipitation, etc, and animal models of cancer. Send or email curriculum vitae and the names of three references to either:

Mark R. Kelley, Ph.D. or Melissa Fishel, Ph.D.
Herman B Wells Center for Pediatric Research
R4 302
1044 West Walnut
Indianapolis, IN 46202
Email: mkelley@iu.edu or mfishel@iu.edu

Indiana University is an EEO/AA employer (M/F/D)

AROUND THE CANCER WORLD (including updates from ASTRO)

Case Western Reserve/University Hospitals Case Medical Center

Cold Spring Harbor Laboratory

Dana-Farber Cancer Institute

Fred Hutchinson Cancer Research Center

Harvard/Beth Israel Deaconness

Harvard School of Public Health

Harvard University

Johns Hopkins


Mayo Clinic

MD Anderson Cancer Center

Memorial Sloan-Kettering


Moffitt Cancer Center

New York University/Langone

The Ohio State University

Oregon Health and Science University

Sanford-Burnham Medical Research Institute

Stanford University

St. Jude Children’s Research Hospital

SUNY Buffalo

University of Alabama at Birmingham

University of California, Davis

University of California Los Angeles

University of California San Diego

University of California, San Francisco

University of Chicago Medicine

University of Michigan

University of North Carolina School of Medicine

University of Pennsylvania/Perelman School of Medicine

University of Southern California

University of Texas Southwestern

University of Utah Huntsman Cancer Institute/Brigham Young University

Wake Forest Baptist Medical Center

Washington University

The Wistar Institute

Yale University






Please note that funding opportunities are now published and distributed on a weekly basis and are no longer included in the Cancer Center Update.

This newsletter is a publication of the University of Illinois Hospital and Health Sciences System Cancer Center. Please contact Dawn Smith at dawnesmi@uic.edu to submit information for publication.








In this issue


Cancer Center News

upcoming events

Recent Publications



Got Cancer Center News?

Send an email to dawnesmi@uic.edu to submit news, events, publication acknowledgements or other information you would like shared with the Cancer Center!








Targeting Cancer: Annual Update in Oncology Pharmacy
October 5, 2013; 9:00 am – 2:30 pm

UIC College of Pharmacy, 833 S. Wood St., Rm.134-1

A conference for pharmacists and other health care professionals who care for patients with cancer.
Edward Li, PharmD, BCOP
Virginia Kaklamani, MD, DSc
Seema Patel, PharmD
Nancy Shapiro, PharmD, FCCP, BCPS
Karen Sweiss, PharmD, BCOP
Scott Wirth, PharmD, BCOP
Click here for more information and to register.


Mircobiology Department Seminar
October 7, 2013; 12:00 pm; COMRB, 909 S. Wolcott, Room 1020

Featuring Dr. A. Scott Muerhoff, Abbott Diagnostics

“New Technologies for Acceleration of Biologic Reagent Discovery.”


UIC Diabetes and Obesity Research Day
October 8, 2013

Presentation, Keynote Lecture and Oral Talks: 1:00 – 5:00 pm; COMRB 909 S. Wolcott, Moss Auditorium

Reception and Poster Session: 5:00 – 7:00 pm; COM, 1856 W. Polk St., Faculty and Alumni Lounge, CMW 119

Featuring the following keynote speakers:
Samuel Dagogo-Jack, MD, A.C. Mullins Professor in Translational Research, Professor of Medicine, Chief of Endocrinology, Diabetes and Metabolism, Director, CRC University of Tennessee Health Science Center in Memphis, TN

Graeme Bell, PhD, Louis Block Distinguished Service Professor, Departments of medicine and Human Genetics, Director, Diabetes Research and Training Center, University of Chicago

Steven Smith, MD, Professor and Scientific Director, Translational Research, Institute for Metabolism and Diabetes, Sanford Burnham Research Institute, Florida Hospital, Orlando, FL


Millipore Seminar: Reagent and Research Tool Communication: Maximizing Access to In-house Research Tools and Reagents
October 9, 2013; 11:00 am MBRB, 900 S. Ashland, Herman Auditorium

12:00 pm Lunch in MBRB 3074, 3rd Floor Reading Room

Featuring James Hoberg, EMD Millipore Corporation Representative, “to discuss the business of commercializing research reagents that have been developed in academic laboratories.”

Source:  "Millipore Seminar October 9th 2013." OTM-info.uic.edu. The Board of Trustees of the University of Illinois, 19 Sept. 2013. Web. 19 Sept. 2013. <http://otm-info.uic.edu/Massmails/Millipore_Announcement.html>.


Cancer Biology Program Lecture
October 15, 2013; 12:00 pm; MBRB 900 S. Ashland Ave., Room 1152

Featuring Nathan Ellis, PhD; Associate Professor of Pediatrics and the Institute of Human Genetics, University of Illinois at Chicago; Faculty Director of the Genomics and DNA Sequencing Facilities

“SUMOylation and the regulation of homologous recombination at stalled replication forks”


Institute for Minority Health Research Workshop and Individual ConsultationsWorkshop – October 17, 2013; 8:00 am – 12:00 pm; UIC COMT – Room 106

Consultations – October 17, 2013; 1:00 pm – 5:00 pm; October 18, 2013; 9:00 am – 5:00 pm

UIC CMWW- Suite 246, IMHR Conference room

Featuring J. Scott Osborne, PhD, MPH

“Epidemiologic Research from Idea to Implementation: Preparing an Application, Possibilities for Funding, Submission and Review Processes and Publication of Results”

Urban Global Health Celebration
October 19, 2013;  10:00 am – 4:15 pm; Evening Gala 6:30 pm – 11:30 pm;

UIC Forum, 725 W. Roosevelt Rd.

Hosted by the Department of Medicine

Guest speakers include Honorable Congressman Danny Davis, US representative of the 7th congressional district of Illinois

Abstract submissions can be sent to Krystle Stewart at krystle2@uic.edu.


The Institute for Health Research and Policy Distinguished Lecture
October 22, 2013; 11:00 am – 12:00 pm; MBRB, 900 S. Ashland Ave., Herman Auditorium

Featuring K. "Vish" Viswanath, PhD, Harvard University. Dr. Viswanath serves on the faculty of the Department of Society, Human Development, and Health at the Harvard School of Public Health and of the Center for Community-Based Research at the Dana-Farber Cancer Institute, where he directs the Health Communication Core.

Dr. Viswanath’s work, drawing from literatures in communication science, social epidemiology, and social and health behavior sciences, focuses on translational communication science to influence public health policy and practice. He particularly focuses on understanding and elucidating the relationship between communication inequalities and disparities in public and individual health in diverse populations and the implications for knowledge translation to influence public health practice and policy. Learn more about his work at http://viswanathlab.org.

“The Communications Revolution: Communication Inequalities and Health Disparities”

All UIC faculty, researchers, staff and students are welcome to attend.


Annual Conference on Challenging Topics in OB/GYN
October 24-25, 2013; 8:00 am – 5:15 pm (both dates)

Student Center West, 2nd Fl, 828 S. Wolcott Ave.

Alumni and Friends of OB/GYN Reception held on October 24, 2013 5:15 pm – 6:30 pm;

Mengert Library

Click here for conference speakers, topics and schedule.

Click here to register or contact Josie Tobias at 312-355-0458 pr uic.obgyn.dept@gmail.com


7th Annual Robert H. Costa Memorial Lecture
October 30, 2013; 12:00 pm

MBRB, 900 S. Ashland Ave., Herman Auditorium

Featuring Dr. Scott L. Friedman, MD, Icahn School of Medicine at Mount Sinai, NY, NY; Director, Division of Liver Diseases; Dean for Therapeutic Discovery; Professor of Pharmacology and Systems Biology

“Links from Fibrosis to Hepatocellular Carcinoma”



BLM SUMOylation regulates ssDNA accumulation at stalled replication forks.

Ouyang KJ, Yagle MK, Matunis MJ, Ellis NA.


Cathepsin B Degradable Star-Shaped Peptidic Macromolecules for Delivery of 2-Methoxyestradiol

Shankar R, Samykutty A, Riggin C, Kannan S, Wenzel U, Kolhatkar R.


Chinese smokers’ cigarette purchase behaviors, cigarette prices and consumption: findings from the ITC China Survey.

Huang J, Zheng R, Chaloupka FJ, Fong GT, Li Q, Jiang Y.


Comparison of carboplatin-paclitaxel to docetaxel-cisplatin-5-flurouracil induction chemotherapy followed by concurrent chemoradiation for locally advanced head and neck cancer.             

Herman LC, Chen L, Garnett A, Feldman LE, Smith B, Weichselbaum RR, Spiotto MT.


Differential impact of tobacco control policies on youth sub-populations.

Tauras JA, Huang J, Chaloupka FJ.


Fertility drugs and endometrial cancer risk: results from an extended follow-up of a large infertility cohort.

Brinton LA, Westhoff CL, Scoccia B, Lamb EJ, Trabert B, Niwa S, Moghissi KS.


Food marketing expenditures aimed at youth: putting the numbers in context.

Powell LM, Harris JL, Fox T.


Genetically Encoded Fluorescent Biosensors for Live-Cell Imaging of MT1-MMP Protease Activity.

Ouyang M, Lu S, Wang Y.


Integrative genomics of gene and metabolic regulation by estrogen receptors α and β, and their coregulators

Madak-Erdogan Z, Charm TH, Jiang Y, Liu ET, Katzenellenbogen JA, Katzenellenbogen BS.


Modeling Mood Variation and Covariation Among Adolescent Smokers: Application of a Bivariate Location-Scale Mixed Effects Model

Pugach O, Hedeker D, Richmond MJ, Sokolovsky A, Mermelstein R.


Methods for Identifying Translational Researchers

Feeney MK, Johnson T, Welch EW


Multifactorial Understanding of Ion Abundance in Tandem Mass Spectrometry Experiments.

Fazal Z, Southey BR, Sweedler JV, Rodriguez-Zas SL.


Non-small cell lung cancer is susceptible to induction of DNA damage responses and inhibition of angiogenesis by telomere overhang oglionucleotides.

Puri N, Pitman RT, Mulnix RE, Erickson T, Iness AN, Vitali C, Zhao Y, Salgia R.


Ovulation-inducing drugs and ovarian cancer risk: results from an extended follow-up of a large US infertility cohort.

Trabert B, Lamb EJ, Scoccia B, Moghissi Kamran, Westhoff CL, Niwa S, Brinton LA


Patient barriers to follow-up care for breast and cervical cancer abnormalities.

Tejeda S, Darnell JS, Cho YI, Stolley MR, Markossian TW, Calhoun EA.


Policy Decisions on Endocrine Disruptors Should Be Based on Science Across Disciplines: A Response to Dietrich et al.

Gore AC, Balthazart J, Bikle D, Carpenter DO, Crews D, Czernichow P, Diamanti-Kandarakis E, Dores RM, Grattan D, Hof PR, Hollenberg AN, Lange C, Lee AV, Levine JE, Millar RP, Nelson RJ, Porta M, Poth M, Power DM, Prins GS, Ridgway EC, Rissman EF, Romijn JA, Sawchenko PE, Sly PD, Söder O, Taylor HS, Tena-Sempere M, Vaudry H, Wallen K, Wang Z, Wartofsky L, Watson CS.


Potentially missed detection with screening mammography.: does the quality of radiologist’s interpretation vary by patient socioeconomic advantage/disadvantage?

Rauscher GH, Khan JA, Berbaum ML, Conant EF


Recruiting and engaging smokers in treatment in a primary care setting: developing a chronic care model implemented through a modified electronic health record.

Piper ME, Baker TB, Mermelstein R, Collins LM, Fraser DL, Jorenby DR, Smith SS, Christiansen BA, Schlam TR, Cook JW, Oguss M, Fiore MC


Risk of glaucoma after early bilateral oophorectomy.

Valjaranant TS, Grossardt BR, Maki PM, Pasquale LR, Sit AJ, Shuster LT, Rocca WA.


Role of microRNA-138 as a potential tumor suppressor in head and neck squamous cell carcinoma.

Jin Y, Chen D, Cabay RJ, Wang A, Crowe DL, Zhou X.


Quantitative FRE imaging to visualize the invasiveness of live breast cancer cells.

Lu S, Wang Y, Huang H, Pan Y, Chaney EJ, Boppart SA, Ozer H, Strongin AY, Wang Y.


Single nucleotide polymorphisms and haplotypes associated with feed efficiency in beef cattle.

Serão NV, González-Peña D, Beever JE, Faulkner DB, Southey BR, Rodriguez-Zas SL.


State costs of excessive alcohol consumption, 2006.

Sacks JJ, Roeber J, Bouchery EE, Gonzales K, Chaloupka FJ, Brewer RD.


State laws governing school meals and disparities in fruit/vegetable intake.

Taber DR, Chriqui JF, Chaloupka FJ.


Sugar-sweetened beverage consumption in the U.S.: novel assessment methodology.

Miller PE, McKinnon RA, Krebs-Smith SM, Subar AF, Chriqui J, Kahle L, Reedy J.


Vitamin k2, a naturally occurring menaquinone, exerts therapeutic effects on both hormone-dependent and hormone-independent prostate cancer cells.

Samykutty A, Shetty AV, Dakshinamoorthy G, Kalyanasundaram R, Zheng G, Chen A, Bosland MC, Kajsacsy-Balla A, Gnanasekar M.


Yoga, vertebral fractures, and osteoporosis: research and recommendations.

Smith EN, Boser A.


Jalees Rehman, MD, Associate Professor of Medicine, Section of Cardiology and Pharmacology, authored the article Cancer research in crisis: Are the drugs we count on based on bad science?

Rehman, Jalees, MD. "Cancer Research in Crisis: Are the Drugs We Count on Based on Bad Science?" Salon.com. Salon Media Group, Inc., 1 Sept. 2013. Web. 30 Sept. 2013






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