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ORIGINAL ARTICLES

  1. Bland, R.D., T.N. Hansen, C.M. Haberkern, M.A. Bressack, T.A. Hazinski, J. U. Raj,  and R.B. Goldberg.  Lung fluid balance in lambs before and after birth.  J. Appl. Physiol. 53:992-1004, 1982.
  2. Raj, J. U., and R.D. Bland.  Neutrophil depletion does not prevent oxygen-induced lung injury in rabbits.  Chest. 3:20S, 1983.
  3. Raj, J. U., R.B. Goldberg and R.D. Bland.  Vibratory ventilation decreases filtration of fluid in the lungs of newborn lambs.  Circ. Res. 53:456-463, 1983.
  4. Raj, J. U., T.A. Hazinski and R.D. Bland.  Oxygen-induced lung microvascular injury in neutropenic rabbits and lambs. J. Appl. Physiol. 58:456-463, 1985.
  5. Raj, J. U., R.D. Bland and S.J. Lai-Fook.  Microvascular pressures measured by micropipettes in isolated edematous rabbit lungs.  J. Appl. Physiol. 60:539-545, 1986.
  6. Raj, J. U., and R.D. Bland.  Lung luminal liquid clearance in newborn lambs: Effect of pulmonary microvascular pressure elevation.  Am. Rev. Respir. Dis. 134:304-310, 1986.
  7. Raj, J. U., P. Chen and L. Navazo.  Micropuncture measurement of lung microvascular pressure profile in 3-4 week old rabbits.  Pediatr. Res. 20:1107-1111, 1986.
  8. Raj, J. U.,  and P. Chen.  Microvascular pressures measured by micropuncture in isolated perfused lamb lungs.  J. Appl. Physiol. 61:2194-2201, 1986.
  9. Raj, J. U., and P. Chen.  Micropuncture measurement of microvascular pressures in lamb lungs during hypoxia.  Circ. Res. 59:398-404, 1986.
  10. Raj, J. U.,  P. Chen and L. Navazo.  Effect of inflation on microvascular pressures in lungs of young rabbits. Am. J. Physiol. 252:H80-H84, 1987.
  11. Raj, J. U., R.L. Conhaim and J. Bhattacharya.  Micropuncture measurement of alveolar liquid pressure in excised dog lung lobes.  J. Appl. Physiol. 62:781-784, 1987.
  12. Raj, J. U.,  Alveolar liquid pressure measured by micropuncture in isolated lungs of mature and immature fetal rabbits.  J. Clin. Invest. 79:1579-1588, 1987.
  13. Raj, J. U., and P. Chen.  Effect of edema on segmental vascular resistance in isolated lamb lungs determined by micropuncture.  Circ. Res. 61:236-243, 1987.
  14. Raj, J. U., and P. Chen.  Role of eicosanoids in hypoxic vasoconstriction in isolated perfused lamb lungs.  Am. J. Physiol. 253:H626-H633, 1987.
  15. Teague, W.G., Jr., J. U. Raj,  D. Braun, M.E. Berner, R.I. Clyman and R.D. Bland.  Lung vascular effects of lipid infusion in normal lambs.  Pediatr. Res. 22:714-719, 1987.
  16. Raj, J. U., T.A. Hazinski and R.D. Bland.  Effect of hypoxia on lung lymph flow in newborn lambs with left atrial hypertension.  Am. J. Physiol. 254:H487-H493, 1988.
  17. Raj, J. U., R. Ramanathan, P. Chen and J. Anderson.  Effect of hematocrit on microvascular pressures in 3-5 week old rabbit lungs.  Am. J. Physiol. 256:H766-H771, 1989.
  18. Ramanathan, R., G.R. Mason and J. U.  Raj. Effect of mechanical ventilation and barotrauma on pulmonary clearance of 99m technetium diethylenetramine pentaacetate in lambs.  Pediatr. Res. 27:70-74, 1990.
  19. Raj, J. U., and J. Anderson.  Pulmonary venous responses to thromboxane A2 analogue and atrial natriuretic peptide in lambs.  Circ. Res. 66:496-502, 1990.
  20. Seear, M., V. Hannam, P. Kaapa, J. U. Raj, and H.M. O'Brodovich.  Effect of pentoxifylline on hemodynamics, alveolar fluid reabsorption, and pulmonary edema in a model of acute lung injury.  Am. Rev. Respir. Dis. 142: 1083-1087, 1990.
  21. Raj, J. U., R. Hillyard, P. Kaapa, M. Gropper and J. Anderson.  Pulmonary arterial and venous constriction during hypoxia in 3-5 week old and adult ferrets.  J. Appl. Physiol. 69: 2183-2189, 1990.
  22. Raj, J. U., R. Hillyard, P. Kaapa, J. Anderson, and M. Gropper.  Pulmonary vascular pressure profile in 2-3 week old, 5-6 week old and adult ferrets. Respir. Physiol. 82:307-316, 1990.
  23. Raj, J. U., and J. Anderson.  Erythrocyte deformability and lung segmental vascular resistance: effect of hematocrit. J. Appl. Physiol. 70:1386-1392, 1991.
  24. Hillyard, R., J. Anderson, and J. U. Raj.  Segmental vascular resistance in isolated perfused rat lungs: influence of vasomotor tone and cyclo- and lipoxygenase inhibition.  Circ. Res. 68:1020-1026, 1991.
  25. Ibe, B.O., W. Isenberg and J. U. Raj. Endogenous arachidonic acid metabolism by neonatal lamb lungs stimulated with calcium ionophore A23187:  Effect of hypoxia.  Am. J. Respir. Cell Mol. Biology. 4:379-385, 1991.
  26. Raj, J. U., and J. Anderson.  Comparison of dextran and hematocrit effects in the pulmonary microcirculation.  Circ. Res. 68:1108-1116, 1991.
  27. Hillyard, R., J. Anderson, and J. U. Raj.  Effect of edema on segmental vascular resistance in isolated perfused rat lungs. Lung. 169:97-108, 1991.
  28. Raj, J. U.,  P. Kaapa, R. Hillyard, and J. Anderson.  Pulmonary vascular pressure profile in adult ferrets: Measurements in vivo and in isolated lungs.  Acta Physiologica Scandinavica. 142:41-48, 1991.
  29. Toga, H., J. U. Raj, R. Hillyard, B. Ku, and J. Anderson.  Endothelin effects in isolated perfused lamb lungs: Role of cyclooxygenase inhibition and vasomotor tone. Am. J. Physiol. 261: H443-H450, 1991.
  30. Kaapa, P., J. U. Raj, R. Hillyard and J. Anderson.  Segmental vascular resistance during pulsatile and steady flow perfusion in 3-to-5 week old rabbit lungs. Am. J. Physiol. 261: H506-H513, 1991.
  31. Kaapa, P., J. U. Raj, B.O. Ibe, and J. Anderson.  Vasoconstrictor response to prostacyclin in rabbit pulmonary circulation. Respir. Physiol. 85: 193-204, 1991.
  32. Filler, S., B.O. Ibe, P.M. Luckett, J. U. Raj,  and J.E. Edwards, Jr. Candida stimulates endothelial cell eicosanoid production. J. Infect. Dis. 164: 928-935, 1991.
  33. Kaapa, P., J. U. Raj, B.O. Ibe, and J. Anderson.  Effect of Pentoxifylline in rabbit pulmonary circulation: Influence of age and vasomotor tone. Am. J. Physiol. 261: H975-H981, 1991.
  34. Ibe, B.O., and J. U. Raj.   Metabolism of endogenous arachidonic acid by isolated lungs of neonatal and adult rabbits stimulated with calcium ionophore: Effect of hypoxia. Exp. Lung Res. 18: 69-85, 1992.
  35. Raj, J. U., P. Kaapa, and J. Anderson.  Effect of pulsatile flow on microvascular resistance in adult rabbit lungs. J. Appl. Physiol. 72: 73-81, 1992.
  36. Raj, J. U., and J. Anderson.  Regional differences in interstitial fluid albumin concentration in edematous lamb lungs. J. Appl. Physiol. 72: 699-705, 1992.
  37. Ibe, B.O., and J. U. Raj.   Endogenous arachidonic acid metabolism by calcium ionophore stimulated ferret lungs: effect of age, hypoxia. Lab. Invest. 66: 370-377, 1992.
  38. Raj, J. U.,  H. Toga, B.O. Ibe, and J. Anderson.  Effects of endothelin, platelet activating factor and thromboxane A2 in ferret lungs. Respir. Physiol. 88: 129-140, 1992.
  39. Toga, H., B.O. Ibe, and J. U. Raj.   In vitro responses of ovine intrapulmonary arteries and veins to endothelin-1: effect of age. Am. J. Physiol. 263: L15-L21, 1992.
  40. Raj, J. U.,  P. Kaapa, and J. Anderson.  Age related differences in vascular effects of pentoxifylline isolated perfused ferret lungs. Dev. Pharmacol. Therap. 18: 1-8, 1992.
  41. Toga, H., S. Hibler, B.O. Ibe, and J. U. Raj.   Vascular effects of platelet activating factor in lambs: role of cyclo- and lipoxygenase. J. Appl. Physiol. 73: 2559-2566, 1992.
  42. Cummings, J.J., D.P. Carlton, F.P. Poulain, J. U. Raj and R.D. Bland. Hypoproteinemia slows lung liquid clearance in young lambs. J. Appl. Physiol. 74:153-160, 1993.
  43. Bansal, V., H. Toga, and J. U. Raj.  Tone dependent nitric oxide production in ovine vessels in vitro. Respir. Physiol. 93: 249-260, 1993.
  44. Filler, S.G., B.O. Ibe, A.S. Ibrahim, M.A. Ghannoum, J. U. Raj, and J.E. Edwards, Jr. Mechanisms by which Candida albicans induces endothelial cell prostaglandin synthesis. Infection and Immunity. 62:1064-69, 1994.
  45. Ibe, B.O., J. Kurantsin-Mills, J. U. Raj, and L.S. Lessin. Plasma and urinary leukotrienes in sickle cell disease: Possible role in the inflammatory process. Europe. J. Clin. Invest. 24:57-64, 1994.
  46. Kurantsin-Mills, J., B.O. Ibe, J. U. Raj, and L.S. Lessin. Elevated plasma and urinary levels of thromboxane metabolites in sickle cell disease: Evidence for activated platelets in the circulation. Br. J. Hematology. 87:580-85, 1994.
  47. Ibe, B.O., and J. U. Raj.  Metabolism of N-Methylcarbazole by rat lung microsomes. Exp. Lung Res. 20:207-22, 1994.
  48. Ibe, B.O., and J. U. Raj. Developmental differences in production of lipoxygenase metabolites by ovine lungs. Exp. Lung Res. 21:385-405, 1995.
  49. Gao, Y., H. Zhou, and J. U. Raj. Heterogeneity in role of endothelium-derived NO in pulmonary arteries and veins of full-term fetal lambs. Am. J. Physiol. 268:H1586-H1592, 1995.
  50. Gao, Y., H. Zhou, and J. U. Raj. Endothelium-derived nitric oxide plays a larger role in pulmonary veins than in arteries of newborn lambs. Circ. Res. 76:559-565, 1995.
  51. Gao, Y., H. Zhou, and J. U. Raj. PAF induces relaxation of pulmonary arteries but contraction of pulmonary veins in the ferret. Am. J. Physiol. 269:H704-H709, 1995.
  52. Gao, Y., H. Zhou and J. U. Raj. Antenatal betamethasone potentiates endothelium-derived nitric oxide induced relaxation of preterm ovine coronary arteries. Am. J. Physiol. 270:H538-H544, 1996.
  53. Zhou, H., Y. Gao, and J. U. Raj. Antenatal betamethasone therapy potentiates endothelium derived nitric oxide induced relaxation of preterm ovine pulmonary veins. J. Appl. Physiol. 80:390-396, 1996.
  54. Hibler, S., H. Toga, and J. U. Raj.  Differential role of endothelium derived nitric oxide in regulation of the systemic and pulmonary circulations in lambs. Biology of the Neonate. 69:84-93, 1996.
  55. Salva, A.M., B.O. Ibe, E. Cliborn, G. Reyes, and J. U. Raj. Hypoxia attenuates metabolism of platelet activating factor by fetal and newborn lamb lungs. J. Lipid Res. 37:783-89, 1996.
  56. Ibe, B.O., A.C. Okogbule-Wonodi, and J. U. Raj. Antenatal glucocorticoid treatment attenuates immediate postnatal prostacyclin and thromboxane levels in plasma of very preterm lambs. Biology of the Neonate. 69:153-164, 1996.
  57. Ibe, B.O., R. Hillyard, and J. U. Raj.  Heterogeneity in prostacyclin and thromboxane synthesis in ovine pulmonary vascular tree: Effect of age and oxygen tension. Exp. Lung Res. 22:351-374, 1996.
  58. Toga, H., V. Bansal, and J. U. Raj.  Differential responses of ovine intrapulmonary arteries and veins to acetylcholine. Respir. Physiol. 104: 197-204, 1996.
  59. Matsuda, M., J. Anderson-Morris, and J. U. Raj.  Microvascular pressures in isolated perfused immature lamb lungs: Effects of flow rate, left atrial pressure and surfactant therapy. Biology of the Neonate, 70:349-358, 1996.
  60. Gao, Y., H. Zhou, B.O. Ibe, and J. U. Raj.  Prostaglandin E2 and I2 cause greater relaxations in pulmonary veins than in arteries of newborn lambs. J. Appl. Physiol. 81:2534-2539, 1997.
  61. Ibe, B.O., J.M. Anderson, and J. U. Raj.  Leukotriene synthesis by isolated perinatal ovine intrapulmonary vessels correlates with age-related changes in 5-lipoxygenase protein. Biochem Mol. Med. 61: 63-71, 1997.
  62. Ibe, B.O., J. Morris, J. Kurantsin-Mills, and J. U. Raj. Sickle erythrocytes induce prostacyclin and thromboxane synthesis by isolated perfused rat lungs. Am J. Physiol 272:  L597-L602, 1997.
  63. S. Oh, B.O. Ibe, C. Johnson and J. U. Raj. Platelet activating factor in plasma of sickle cell disease patients in steady state. J. Lab. Clin. Med.  130:191-6, 1997.
  64. Gao, Y. H. Zhou, J-F. Tolsa, H. Shen, and J. U. Raj.  Antenatal betamethasone therapy augments isoproterenol and prostaglandin E2-mediated relaxation of preterm ovine pulmonary veins. Ped. Res. 42:545-549, 1997.
  65. Gao, Y., J-F. Tolsa, H. Shen, and J. U. Raj. Effect of selective phosphodiesterase inhibitors on response of ovine pulmonary arteries to prostaglandin E2.  J. Appl. Physiol. 84:13-18, 1998.
  66. Gao, Y., J-F. Tolsa, H. Shen, and J. U. Raj.  Single dose of antenatal betamethasone enhances isoprenaline and prostaglandin E2-induced relaxation of preterm ovine pulmonary arteries. Biol. Neonate. 73:182-189, 1998.
  67. Gao Y, J-F. Tolsa, M. Botello and J. U. Raj. Developmental change in isoproterenol-mediated relaxation of pulmonary veins of fetal and newborn lambs. J Appl Physiol. 84:1535-1539, 1998.
  68. Ibe, B.O., S. Hibler, and J. U. Raj.  Platelet activating factor modulates pulmonary vasomotor tone in the perinatal lamb. J. Appl. Physiol. 85:1079-85, 1998.
  69. Gao, Y., J-F. Tolsa, and J. U. Raj. Heterogeneity in endothelium-derived nitric oxide-mediated relaxation of different sized pulmonary arteries of newborn lambs. Ped. Res. 44:723-729, 1998.
  70. Okogbule-Wonodi, A.C., B.O. Ibe, B. W. Yue, S. Hsu, and J. U. Raj. Phosphodiesterase activity in intrapulmonary arteries and veins of perinatal lambs. Mol. Gen. Met. 65: 229-237, 1998.
  71. Y. Gao, S.R. Dhanakoti, J-F Tolsa, and J.U. Raj.  Role of protein kinase G in nitric oxide- and cGMP-induced relaxation of newborn ovine pulmonary veins. J. Appl. Physiol. 87:993-998, 1999.
  72. Tolsa, J-F., Y. Gao, and J. U. Raj. Developmental change in magnesium sulfate-induced  relaxation of rabbit pulmonary arteries. J. Appl. Physiol. 87:1589-1594, 1999.
  73. Kolber, K., Y. Gao, and J.U. Raj. Maturational changes in endothelium-derived nitric oxide-mediated relaxation of ovine pulmonary arteries. Biology of the Neonate. 77:123-130, 2000.
  74. Ibe, B.O., F.C. Sander, and J. U. Raj.  Platelet activating factor acetylhydrolase activity in lamb lungs is up-regulated in the immediate newborn period. Mol Genet Metab 69:45-55, 2000.
  75. Ibe, B.O., F. C. Sander, and J.U. Raj. Platelet-activating factor receptors in lamb lungs are down-regulated immediately after birth. Am J Physiol  278:H1168-1176, 2000.
  76. Dhanakoti, S.R., Y. Gao, MQ Nguyen, and J.U. Raj. Involvement of cGMP-dependent protein kinase in the relaxation of ovine pulmonary arteries to cGMP and cAMP. J. Appl. Physiol, 88:1637-1642, 2000.
  77. Gao, Y., and J.U. Raj. SQ22536 and W-7 inhibit Forskolin-induced cAMP elevation but not relaxation in newborn ovine pulmonary veins. Eur. J. Pharm. 418: 111-116, 2001.
  78. Ibe, B.O., and J.U. Raj. Leukotriene Metabolism by Intrapulmonary Vessels of Newborn Lambs: Effect of Platelet Activating Factor. Exp. Lung Res. 27: 331-48, 2001.
  79. Ibe, B.O., H.H. Pham, P. Kaapa, and J.U. Raj. Maturational changes in ovine pulmonary metabolism of Platelet Activating Factor: Implications for Postnatal adaptation. Mol Gen Metabolism, 74: 385-95,2001.
  80. Tolsa, Jean-Francois, Y. Gao, F. Sander, A-C. Souici, A. Moessinger, and J.U. Raj. Differential responses of pulmonary arteries and veins of newborn lamb to Atrial and C-type natriuretic peptides. Am. J. Physiol, 282:H273-H280, 2002.
  81. Gao, Y., and J.U. Raj. Effects of SQ22536, an adenylyl cyclase inhibitor, on isoproterenol-induced cAMP elevation and relaxation in newborn ovine pulmonary veins. Eur. J. Pharm. 436:227-233, 2002.
  82.  Raj, J.U. and L. Shimoda. Oxygen-dependent signaling in pulmonary vascular smooth muscle. AJP: Lung Cell Mol Physiol 283:L671-677, 2002.
  83. Ibe, B.O., A. M. Portugal, and J.U. Raj. Metabolism of platelet activating factor by intrapulmonary vascular smooth muscle cells. Effect of oxygen on phospholipase A2 protein expression and activities of acetyl-CoA acetyltransferase and cholinephosphotransferase. Mol. Gen. Metabolism, 77:237-248, 2002.
  84. Gao, Y., S.N. Dhanakoti, E.M. Trevino, F.C. Sander, A.M. Portugal, and J.U. Raj.  SN, Effect of oxygen on cyclic GMP-dependent protein kinase-mediated relaxation in ovine fetal pulmonary arteries and veins. AJP: Lung Cell Mol Physiol, 285:L611-L618, 2003.
  85. Gao, Y., S.N. Dhanakoti, E.M. Trevino, X. Wang, F.C. Sander, A.M. Portugal, and J.U. Raj. Role of cGMP-dependent Protein Kinase in development of tolerance to nitric oxide in pulmonary veins of newborn lambs. AJP: Lung Cell Mol Physiol 286:L786-92, 2004.
  86. Joyce, J.J., P.I. Dickson, N.Qi, J.E. Noble, J.U. Raj, and B.G. Baylen. Normal right and left ventricular mass development during early infancy. Am J Cardiol 15:93(6):797-801, 2004.
  87. Ibe, B.O., A.M. Portugal, S. Chaturvedi, and J.U. Raj. Oxygen-dependent PAF-receptor binding and intracellular signaling in ovine fetal pulmonary vascular smooth muscle. AJP: Lung Cell Mol Physiol, 288(5):L879-86, 2005.
  88. Gao,Y. and J. U. Raj. “Parathyroid Hormone Related Protein Mediated Responses in Pulmonary Arteries and Veins of Newborn Lambs”. AJP: Lung Cell Mol Physiol , 289: L60-66, 2005.
  89. Sander, F., Y. Gao,  and J. U. Raj. Hypoxia down-regulates cyclic guanidine monophosphate-dependent protein kinase in fetal pulmonary vascular smooth muscle cell through generation of reactive oxygen species and promotes development of pulmonary hypertension. Chest,128:577S-578S, 2005.
  90. Wang, X., M. Tong, S. Chinta, J. U. Raj, and Y. Gao. Hypoxia-induced Reactive Oxygen Species Downregulate ETB-receptor-mediated Contraction of Rat Pulmonary Arteries. AJP: Lung Cell Mol Physiol, 290:L570-8. 2006. Epub 2005 Oct 14.
  91. Y. Gao and J. U. Raj. Role of Veins in Regulation of the Pulmonary Circulation. AJP: Lung Cell Mol Physiol, 288:L213-26, 2005.
  92. Ibe, B.O., A. Portugal, and J.U. Raj. Levalbuterol inhibits human airway smooth muscle cell proliferation: therapeutic implications in management of asthma. Int Arch Allergy and Immunology, 139:225-36, 2006.  Epub Jan 2006.
  93. John, T. A., B.O. Ibe, and J.U. Raj. Oxygen alters Caveolin-1 and Nitric Oxide Synthase-3 functions in ovine fetal and neonatal lung microvascular endothelial cells. AJP: Lung Cell Mol Physiol, 291(5):L1079-93, 2006. Epub 2006 Sep 22.
  94. Ibe, B.O., A. Ameer, A.Portugal, L. Renteria, and J.U. Raj. Platelet Activating Factor Modulates Activity of Cyclic Nucleotides in Fetal Ovine Pulmonary Vascular Smooth Muscle. J Pharmacol Exp Therap, 320(2):728-37. 2007, Epub, Nov 2006.
  95. Gao, Y., A. Portugal, S. Negash, W. Zhou, L.D. Longo, and J.U. Raj. Role of Rho Kinases in PKG-Mediated Relaxation of Pulmonary Arteries of Fetal Lambs Exposed to Chronic High Altitude Hypoxia. AJP: Lung Cell Mol Physiol, 292: L678 - L684, 2007.
  96. Zhou, W., C. Dasgupta, S. Negash, and J.U. Raj. Modulation of Pulmonary Vascular Smooth Muscle Phenotype in Hypoxia: Role of cGMP-Dependent protein Kinase. AJP: Lung Cell Mol Physiol;292(6):L1459-66, 2007; [Epub ahead of print], 2007.
  97. Zhou, W., B.O. Ibe, and J.U. Raj. Platelet Activating Factor Receptor-Induced Ovine Fetal Pulmonary Vascular Smooth Muscle Cell Proliferation is mediated by Transactivation of Epidermal Growth Factor Receptor and MAPK Phosphorylation. AJP: Heart Circulation Physiol;292(6):H2773-81, 2007; Epub Feb 23; 2007.
  98. Qin, X., X. Zheng, H. Qi, D. Dou, J. U. Raj, and Y. Gao. cGMP-Dependent Protein Kinase in Regulation of Basal Tone and in Nitroglycerin and Nitric Oxide Induced Relaxation in Porcine Coronary Artery. Pflugers Arch Euro Journal Physiol;454(6):913-23, 2007; [Epub ahead of print], 2007.
  99. Negash, S., Y. Gao, W. Zhou, S. Chinta, J. Liu, and J.U. Raj. Regulation of cGMP-Dependent Protein Kinase (PKG1) Mediated Vasodilation by Hypoxia-Induced Reactive Species in Ovine Fetal Pulmonary Veins. AJP: Lung Cell Mol Physiol;293(4):L1012-20, 2007.
  100. John, T.A., B.O. Ibe and J.U. Raj. Regulation Of Endothelial Nitric Oxide Synthase: Involvement of Protein Kinase G ß, Serine 116 Phosphorylation And Lipid Structures.  Clinical and Experimental Pharmacology and Physiology; 35(2):148-58, 2008. Epub, 2007.
  101. Qi, H., X. Zheng, X. Qin, D. Dou, H. Xu, J.U. Raj, and Y. Gao. PKG Regulates the Basal Tension and Plays a Major Role in Nitrovasodilator-Induced Relaxation of Porcine Coronary Veins. British J Pharmacol; 152(7):1060-9, 2007; Epub 2007.
  102. Bixby, C.E., B.O. Ibe, M.F. Abdallah, A.A. Hislop, L.D. Longo, and J.U. Raj. Role of Platelet Activating Factor in Pulmonary Vascular Remodeling Associated with Chronic High-Altitude Hypoxia in Ovine Fetal Lambs, AJP: Lung Cell Mol Physiol; 293(6):L1475-82, 2007.
  103. Dou, D., X. Zheng, X. Qin, H. Qi, L. Liu, J. U. Raj, and Y. Gao. Role of PKG in Development of Nitroglycerin Tolerance of Porcine Coronary Arteries. British Journal of Pharmacology; 153(3):497-507, 2008.
  104. Ibe, B.O., M. Abdallah, A. D. Portugal, and J.U. Raj. Platelet Activating Factor stimulates ovine fetal pulmonary vascular smooth muscle cell proliferation: Role of nuclear factor-kappa beta and cyclin dependent kinases. Cell Proliferation; 41(2):208-29, 2008.
  105. Ibe, B.O., M. Abdallah, and J.U. Raj. Mechanisms by which (S)-albuterol induces human bronchial smooth muscle cell proliferation. Int Arch Allergy and Immunology; 146(4):321-333, 2008.
  106. Gao, Y., A.D. Portugal, J. Liu, S. Negash, W. Zhou, J. Tian, R. Xiang, L. D. Longo, and J.U. Raj. Preservation of cGMP-induced relaxation of pulmonary veins of fetal lambs exposed to chronic high altitude hypoxia: role of PKG and Rho kinase. AJP: Lung Cell Mol Physiol, 295(5):L889-96, 2008. Epub 2008 Aug 29. 2008.
  107. Liu, J., Y. Gao, S. Negash, L.D. Longo, and J.U. Raj. Long-term effects of prenatal hypoxia on endothelium-dependent relaxation responses in pulmonary arteries of adult sheep. AJP: Lung Cell Mol Physiol, Mar; 296(3):L547-54. Epub 2009 Jan 9, 2009.
  108. Zhou, W., S. Negash, J. Liu, and J. U. Raj. Modulation of Pulmonary Vascular Smooth Muscle Cell phenotype in hypoxia: Role of cGMP-Dependent Protein Kinase and Myocardin. AJP: Lung Cell Mol Physiol, May;296(5):L780-9; Feb 27. [Epub ahead of print, 2009.
  109. Castro M, Ramirez MI, Gern JE, Cutting G, Redding G, Hagood JS, Whitsett J, Abman S, Raj JU, Barst R, Kato GJ, Gozal D, Haddad GG, Prabhakar NR, Gauda E, Martinez FD, Tepper R, Wood RE, Accurso F, Teague WG, Venegas J, Cole FS, Wright RJ. Strategic plan for pediatric respiratory diseases research: an NHLBI working group report Proc Am Thorac Soc. 15;6(1):1-10, 2009.
  110. 110. Abman S, Jobe A, Chernick V, Blaisdell C, Castro M, Ramirez MI, Gern JE, Cutting G, Redding G, Hagood JS, Whitsett J, Abman S, Raj JU, Barst R, Kato GJ, Gozal D, Haddad GG, Prabhakar NR, Gauda E, Martinez FD, Tepper R, Wood RE, Accurso F, Teague WG, Venegas J, Cole FS, Wright RJ, Gail D, Hamvas A, Kercsmar C, Kiley J, Weinmann G; NHLBI working group report. Strategic plan for pediatric respiratory diseases research: an NHLBI working group report, Pediatric Pulmonol, 44(1):2-13, 2009.
  111. Negash, S., S. R.Narasimhan, W. Zhou, J. Liu, F. Wei, and J. U. Raj. Role of cGMP-dependent protein kinase (PKG) in regulation of ovine fetal pulmonary vascular smooth muscle cell adhesion and migration: Effect of hypoxia. AJP: Lung Cell Mol Physiol, Jul;297(1):H304-12. Epub 2009 May 1, 2009.
  112. Sheng, L., W. Zhou, A. A. Hislop, L. D. Longo, B.O. Ibe, and J. U. Raj. Role of Epidermal Growth Factor Receptor in Ovine Fetal Pulmonary Vascular Remodeling Following Exposure to High Altitude Long-Term Hypoxia". High Altitude Medicine & Biology, 10 (4): 365-72, 2009. 
  113. S.H. Abman and U. Raj. Towards improving the care of children with pulmonary hypertension: The rationale for developing a Pediatric Pulmonary Hypertension Network. Progress in Pediatric Cardiology. 27:3-6, 2009.
  114. John, T.A., and J.U. Raj. A fluorescence-activated cell sorter analysis of the relationship between protein kinase G and endothelial nitric oxide synthase. The Anatomical Record, 293: 1755-65, 2010.
  115. Ma, H., Q. He. D. Dou, X. Zheng, L. Ying, Y. Wu, and J. U. Raj, and Y. Gao. Increased Degradation of MYPT1 Contributes to the Development of Tolerance to Nitric Oxide in Porcine Pulmonary Artery.  AJP: Lung Cell Mol Physiol, 299:L117-23, 2010.
  116. Gao, Y. and J. U. Raj. Development and Regulation of the Circulation in the Fetus and Newborn. Physiological Reviews, 90:1291-335, 2010.
  117. Sarkar J., D. Gou, P. Turaka, E. Viktorova, R. Ramchandran, and J. U. Raj. MicroRNA-21 plays a Role in Hypoxia-mediated Pulmonary Artery Smooth Muscle Cell Proliferation and Migration. AJP: Lung Cell Mol Physiol, 299:L861-71, 2010.
  118. Renteria, L.S., J. U. Raj and B.O. Ibe. Prolonged hypoxia modulates platelet activating factor receptor-mediated responses by fetal ovine pulmonary vascular smooth muscle cells. Molecular Genetics and Metabolism, 101:400-8, 2010.
  119. Zhou, Q., A. Pardo, M. Koenigshoff, O. Eickelberg, G.R.S. Budinger, K. Thavarajah, C.J. Gottardi, J. Jones, J. Varga, M. Selman, J. I. Sznajder, J. U. Raj and G. Zhou. Role of von Hippel-Lindau in fibroblast proliferation and fibrosis. Faseb J. (9):3032-44, 2011.
  120. Zhou, Q., T. Chen, J.C. F. Ibe, J. U. Raj, and G. Zhou. Loss of either hypoxia inducible factor 1 or 2 promotes lung cancer cell colonization. Cell Cycle. 10(13):2233-4, 2011.
  121. 121. Cerro MJ, Abman S, Diaz G, Freudenthal AH, Freudenthal F, Harikrishnan S, Haworth SG, Ivy D, Lopes AA, Raj JU, Sandoval J, Stenmark K, Adatia I. A consensus approach to the classification of pediatric pulmonary hypertensive vascular disease: Report from the PVRI Pediatric Taskforce, Panama 2011. Pulm Circ. 1(2):286-298, 2011.
  122. Lammers AE, Adatia I, Cerro MJ, Diaz G, Freudenthal AH, Freudenthal F, Harikrishnan S, Ivy D, Lopes AA, Raj JU, Sandoval J, Stenmark K, Haworth SG. Functional classification of pulmonary hypertension in children: Report from the PVRI pediatric taskforce, Panama 2011. Pulm Circ. Aug 2;1(2):280-285, 2011.
  123. Adebola T, and J.U. Raj. Inhibitors caveolin-1 and protein kinase G show differential subcellular colocalization with Nitric oxide synthase. Afr. Health Science. 4:526-34, 2011.
  124. Singh, D.K., J. Sarkar, A, Raghavan and J. U. Raj. Hypoxia modulates the expression of leucine zipper positive MYPT1 and its interaction with protein kinase G and Rho kinases in pulmonary arterial smooth muscle cells. Pulmonary Circulation, 1:487-98, 2011.
  125. Zhou, Guofei, Q. Zhou, T. Chen, J. Ibe, and J. U. Raj. Knockdown of von Hippel-Lindau Protein decreases lung cancer cell proliferation and colonization. FEBS Lett. 586:1510-5, 2012.
  126. Ramchandran, R., E. Pilipenko, L. Bach, and J. U. Raj. Hypoxia regulation of pulmonary vascular smooth muscle cGMP-dependant kinase by the ubiquitin conjugating system. American Journal of Respiratory Cell and Molecular Biology, 46:323-30, 2012.
  127. Raghavan, A., G. Zhou, Q. Zhou, J.C.F. Ibe, R. Ramachandran, H. Racherla, P. Raychaudhuri, and J. U. Raj. Hypoxia induced pulmonary arterial smooth muscle cell proliferation is controlled by FoxM1. American Journal of Respiratory Cell and Molecular Biology, 46:431-6, 2012.
  128. Bae, R., A. Arteaga, J.U. Raj and B.O. Ibe. Albuterol isomers modulate platelet activating factor synthesis, receptor signaling and leukotriene release in human bronchial smooth muscle cells. International Archives of Allergy and Immunology, 158:18-26, 2012.
  129. Hobin J.A., A.M. Deschamps, R. Bockman, S. Cohen, P. Dechow, C. Eng, W. Galey, M. Morris, S. Prabhakar, J.U. Raj, P. Rubinstein, J.A. Smith, P. Stover, N. Sung, W. Talman, and R. Galbraith. Engaging basic scientists in translational research: identifying opportunities, overcoming obstacles. J. Transl. Med.10:72, 2012.
  130. Yang, Q., Z. Lu, D. Singh, and J. U. Raj. BIX-01294 treatment blocks cell proliferation, migration and contractility in ovine foetal pulmonary arterial smooth muscle cells. Cell Proliferation, 45:335-44, 2012.
  131. Peng, X., Y. Wang, S. Kolli, J. Deng, L. Li, Z. Wang, J. U. Raj, and D. Gou. Physical and functional interaction between the ID1 and p65 for activation of NFκB. AJP: Cell Physiology, 303:C267-77, 2012.
  132. Gu. S., Y. Tian, A. Chlenski, H.R. Satwen, Z. Lu, J. U. Raj, and Q. Yang. Valproic acid shows a potent antitumor effect with alteration of DNA methylation in neuroblastoma. Anticancer Drugs, 23: 1054-66, 2012.
  133. Gou, D., R. Ramchandran, X. Peng, L. Yao., K. Kang, J. Sarkar, Z. Wang, G. Zhou, and J. U. Raj. MiR-210 has an anti-apoptotic effect in pulmonary artery smooth muscle cells during hypoxia. AJP: Lung Cell Mol Physiol, 303:L682-91, 2012.
  134. Shaikh, D., Q. Zhou, J.C.F. Ibe, T. Chen, J. U. Raj, and G. Zhou. cAMP-dependent protein kinase is essential for hypoxia-mediated epithelial-mesenchymal transition, migration, and invasion in lung cancer cells. Cell Signal, 24:2396-406, 2012.
  135. Yang, Q., Z. Lu, R. Ramchandran, L.D. Longo, and J. U. Raj. Pulmonary Artery smooth muscle cell proliferation and migration in fetal lambs acclimatized to high-altitude long-term hypoxia: role of histone acetylation. AJP: Lung Cell Mol Physiol, 303: L1001-10, 2012.
  136. Xu, X., S. Wang, J. Liu, D. Dou, L. Liu, Z. Chen, L. Ye, H. Liu, Q. He, J. U. Raj, and Y. Gao. Hypoxia induces downregulation of soluble guanylate cyclase β1 by miR-34c-5p. J. Cell Sci. 125:6117-26, 2012.
  137. Ye, L., J. Liu, H. Liu, L. Ying, D. Dou, Z. Chen, X. Xu, J. U. Raj, and Y. Gao. Sulfhydryl-dependent dimerization of soluble guanylyl cyclase modulates relaxation of porcine pulmonary vessels to nitric oxide. Pflügers Archiv, European Journal of Physiology, 465:333-41, 2013.
  138. Lu, Z., H.R. Salwen, A. Chlenski, L.A. Godley, J.U. Raj, and Q. Yang. Histone lysine methyltransferase EHMT2 is involved in proliferation, apoptosis, cell invasion and DNA methylation of human neuroblastoma cells. Anticancer Drugs. 24:484-93, 2013.
  139. Abman, S.A., J.P. Kinsella, E.B. Rosenzweig, U. Krishnan, T. Kulik, M. Mullen, D.L. Wessel, R. Steinhorn, I Adatia, B. Hanna, J. Feinstein, J. Fineman, U. Raj, T. Humpl. On behalf of the Pediatric Pulmonary Hypertension Netwrok (PPHNet). Implications of the US FDA Warning Against the Use of Sildenafil for the Treatment of Pediatric Pulmonary Hypertension. Am. J. Respir. Crit. Care Med. In Press, 2013.
  140. Namachivayam, K., C.L. Blanco, B.L. Frost, A.A. Reeves, R. Jagadeeswaran, K. MohanKumar, A. Safarulla, P. Mandal, S.A. Garzon, J.U. Raj, and A. Maheshwari. Preterm Human Milk contains a Large Pool of Latent TGF-β, which can be activated by Exogenous Neuraminidase. Am. J. Physiol, Gastro and Liver, In Press, 2013.
  141. Ibe, J. C. F., J U. Raj, Q. Zhou, T. Chen, G. Zhou. AMPK is required for pulmonary artery smooth muscle cell survival and the development of hypoxic pulmonary hypertension. Am. J. Resp. Cell Mol. Biol. In Press 2013.


    SUBMITTED MANUSCRIPTS

  142. Gou, D., X. Peng, L. Zhang, Y. Wang, L. Gao, K. Kang, L. Yao, T. Weng, H. Zhang, R. Ramchandran, Z. Wang, J. U. Raj, and L. Liu. miR-124 suppresses NFAT transactivation by targeting multiple genes.
  143. John, T.A., and J. U. Raj. Caveolin-1 and Protein Kinase G Show Differential Subcellular Colocalization With Nitric Oxide Synthase.
  144. Ibe, B., L. Renteria, M. Abdallah, M. Lazaro, M. Andrews, J. Lustina, and J. U. Raj Involvement of RhoA-Rho kinase in Platelet Activating Factor Stimulation of Ovine Fetal Pulmonary Vascular Smooth Muscle Cell Proliferation.

 

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BOOKS/CHAPTERS/INVITED REVIEWS

  1. Raj. J. Usha.  Hyaline membrane disease.  In: Neonatal Cardiopulmonary Distress, G. C. Emmanouilides and B.G. Baylen, eds., Yearbook Medical Publishers, Inc., 1987, pp 49-64.
  2. Raj, J. Usha, and G. Franco.  Acid Base, Fluid and Electrolyte Management. In: Schaffer and Avery's Diseases of the Newborn. eds. W. Taeusch, R. Ballard and M.E. Avery.  6th Ed. 1991. W. B. Saunders Company, Harcourt Brace Jovanovitch, Inc. Philadelphia, PA 19106.
  3. Raj, J. Usha. The Role of Physical Factors and Lung Water on Microvascular Pressures and Pulmonary Vascular Resistance. In Proceedings of 100th Anniversary Celebration, Children’s Hospital, Groningen, Holland. Pp 54-59, 1993.
  4. Raj, J. Usha. Effect of the Distribution of Vascular Pressures on Pulmonary Edema. In: Pulmonary Edema. ed. E.K. Weir, J.T. Reeves, Futura Publishing Company, New York. Pp 183-194, 1998 
  5. J-F. Tolsa, J-L. Micheli, Y Gao, and J. Usha Raj. Corticoids antenatals: effets sur l’adapation respiratoire et cardiocirculatoire des nouveau-nes prematures. In: Progres en pediatrie perinatalogie. 7 Le poumon du nouveau-ne”, ed. M. Dehan, J-L. Micheli, Pp 39-47, 2000.
  6. Raj, J. Usha, Y. Gao, S. Dhanakoti and F. Sander. Nitric Oxide and Intracellular Signaling in Lung Vascular Smooth Muscle Cells. Progres en pediatrie perinatalogie, 2004
  7. Raj, J. Usha, Y. Gao, S. Dhanakoti and F. Sander. cGMP-dependent protein kinase in regulation of the perinatal pulmonary circulation. Futura Publishing Company, New York, 2005.
  8. Wang, X, M. Tong, D. Dou, J. U. Raj, and Y. Gao. Role of cGMP-dependent Protein Kinase in the Cardiovascular System. Sheng Li Ke Xue Jin Zhan, Chinese Physiological Society, 36: 299-303, 2005.
  9. Invited Review: Y. Gao and J. U. Raj. cGMP-dependent protein kinase in regulation of the pulmonary circulation. Current Resp Med Reviews, 2:373-381, 2006.
  10. Invited Summary: Raj, J. U. et al. Genomics and Proteomics of Lung Disease: Conference Summary. AJP: Lung Cell Mol Physiol; 293(1):L45-5, 2007; Epub 2007, 2007.
  11. Y. Gao and J. U. Raj. Endothelial Regulation of the Pulmonary Circulation in the Fetus and Newborn. The Pulmonary Endothelium; Function in Health and Disease, Eds. Voelkel and Rounds. Wiley Blackwell, 381-398, 2009.
  12. Y. Gao and J. U. Raj. Hypoxic pulmonary hypertension of the newborn. Comprehensive Physiology, American Physiological Society, 2010.
  13. J. U. Raj and J. R. Wright. Respiratory Distress Syndrome. Pp197-207. Breathing in America: Diseases, Progress and Hope. Ed. D.E. Schraufnagel, ATS Publication, 2010.

 

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