ORIGINAL ARTICLES

  1. Bland, R.D., T.N. Hansen, C.M. Haberkern, M.A. Bressack, T.A. Hazinski, J. U. Raj, and R.B. Goldberg. Lung fluid balance in lambs before and after birth. J. Appl. Physiol. 53:992-1004, 1982. PMID: 7153132
  2. Raj, J. U., and R.D. Bland. Neutrophil depletion does not prevent oxygen-induced lung injury in rabbits. Chest. 3:20S-21S, 1983. PMID: 6839842
  3. Raj, J. U., R.B. Goldberg and R.D. Bland. Vibratory ventilation decreases filtration of fluid in the lungs of newborn lambs. Circ. Res. 53:456-463, 1983. PMID:6627605
  4. Raj, J. U., T.A. Hazinski and R.D. Bland. Oxygen-induced lung microvascular injury in neutropenic rabbits and lambs. J. Appl. Physiol. 58:921-7, 1985. PMID: 3980393
  5. Raj, J. U., R.D. Bland and S.J. Lai-Fook. Microvascular pressures measured by micropipettes in isolated edematous rabbit lungs. J. Appl. Physiol. 60:539-545, 1986. PMID: 3949659
  6. Raj, J. U., and R.D. Bland. Lung luminal liquid clearance in newborn lambs: Effect of pulmonary microvascular pressure elevation. Am. Rev. Respir. Dis. 134:304-310, 1986. PMID:3740657
  7. Raj, J. U., P. Chen and L. Navazo. Micropuncture measurement of lung microvascular pressure profile in 3-4 week old rabbits. Pediatr. Res. 20:1107-1111, 1986. PMID:3797104
  8. Raj, J. U., and P. Chen. Microvascular pressures measured by micropuncture in isolated perfused lamb lungs. J. Appl. Physiol. 61:2194-2201, 1986. PMID:3804926
  9. Raj, J. U., and P. Chen. Micropuncture measurement of microvascular pressures in lamb lungs during hypoxia. Circ. Res. 59:398-404, 1986. PMID:3791581
  10. Raj, J. U., P. Chen and L. Navazo. Effect of inflation on microvascular pressures in lungs of young rabbits. Am. J. Physiol. 252:H80-H84, 1987. PMID:3812720
  11. Raj, J. U., R.L. Conhaim and J. Bhattacharya. Micropuncture measurement of alveolar liquid pressure in excised dog lung lobes. J. Appl. Physiol. 62:781-784, 1987. PMID:3558237
  12. Raj, J. U., Alveolar liquid pressure measured by micropuncture in isolated lungs of mature and immature fetal rabbits. J. Clin. Invest. 79:1579-1588, 1987. PMID:3584460
  13. Raj, J. U., and P. Chen. Effect of edema on segmental vascular resistance in isolated lamb lungs determined by micropuncture. Circ. Res. 61:236-243, 1987. PMID:3621489
  14. Raj, J. U., and P. Chen. Role of eicosanoids in hypoxic vasoconstriction in isolated perfused lamb lungs. Am. J. Physiol. 253:H626-H633, 1987. PMID:2820247
  15. Teague, W.G., Jr., J. U. Raj, D. Braun, M.E. Berner, R.I. Clyman and R.D. Bland. Lung vascular effects of lipid infusion in normal lambs. Pediatr. Res. 22:714-719, 1987. PMID:3431956
  16. Raj, J. U., T.A. Hazinski and R.D. Bland. Effect of hypoxia on lung lymph flow in newborn lambs with left atrial hypertension. Am. J. Physiol. 254:H487-H493, 1988. PMID:3348427
  17. Raj, J. U., R. Ramanathan, P. Chen and J. Anderson. Effect of hematocrit on microvascular pressures in 3-5 week old rabbit lungs. Am. J. Physiol. 256:H766-H771, 1989. PMID:2923236
  18. Ramanathan, R., G.R. Mason and J. U. Raj. Effect of mechanical ventilation and barotrauma on pulmonary clearance of 99m technetium diethylenetramine pentaacetate in lambs. Pediatr. Res. 27:70-74, 1990. PMID:2404254
  19. Raj, J. U., and J. Anderson. Pulmonary venous responses to thromboxane A2 analogue and atrial natriuretic peptide in lambs. Circ. Res. 66:496-502, 1990. PMID:2137039
  20. Seear, M., V. Hannam, P. Kaapa, J. J U. Raj, and H.M. O'Brodovich. Effect of pentoxifylline on hemodynamics, alveolar fluid reabsorption, and pulmonary edema in a model of acute lung injury. Am. Rev. Respir. Dis. 142: 1083-1087, 1990. PMID:2240831
  21. Raj, J. U., R. Hillyard, P. Kaapa, M. Gropper and J. Anderson. Pulmonary arterial and venous constriction during hypoxia in 3-5 week old and adult ferrets. J. Appl. Physiol. 69: 2183-2189, 1990. PMID:2077015
  22. Raj, J. U., R. Hillyard, P. Kaapa, J. Anderson, and M. Gropper. Pulmonary vascular pressure profile in 2-3 week old, 5-6 week old and adult ferrets. Respir. Physiol. 82:307-316, 1990.
  23. Hillyard, R., J. Anderson, and J. U. Raj. Effect of edema on segmental vascular resistance in isolated perfused rat lungs. Lung. 169:97-108, 1991. PMID:2062125
  24. Raj, J. U., and J. Anderson. Erythrocyte deformability and lung segmental vascular resistance: effect of hematocrit. J. Appl. Physiol. 70:1386-1392, 1991. PMID:2033008
  25. Raj, J. U., and J. Anderson. Comparison of dextran and hematocrit effects in the pulmonary microcirculation. Circ. Res. 68:1108-1116, 1991. PMID:1706965
  26. Hillyard, R., J. Anderson, and J. U. Raj. Segmental vascular resistance in isolated perfused rat lungs: influence of vasomotor tone and cyclo- and lipoxygenase inhibition. Circ. Res. 68:1020-1026, 1991. PMID:1901254
  27. Ibe, B.O., W. Isenberg and J. U. Raj. Endogenous arachidonic acid metabolism by neonatal lamb lungs stimulated with calcium ionophore A23187: Effect of hypoxia. Am. J. Respir. Cell Mol. Biology. 4:379-385, 1991. PMID:1901720
  28. Raj, J. U., P. Kaapa, R. Hillyard, and J. Anderson. Pulmonary vascular pressure profile in adult ferrets: Measurements in vivo and in isolated lungs. Acta Physiologica Scandinavica. 142:41-48, 1991. PMID:1877364
  29. Toga, H., Usha Raj J., R. Hillyard, B. Ku, and J. Anderson. Endothelin effects in isolated perfused lamb lungs: Role of cyclooxygenase inhibition and vasomotor tone. Am. J. Physiol. 261: H443-H450, 1991. PMID:1908640
  30. Kaapa, P., Usha Raj J., R. Hillyard and J. Anderson. Segmental vascular resistance during pulsatile and steady flow perfusion in 3-to-5 week old rabbit lungs. Am. J. Physiol. 261: H506-H513, 1991. PMID:1877677
  31. Kaapa, P., J. U. Raj, B.O. Ibe, and J. Anderson. Vasoconstrictor response to prostacyclin in rabbit pulmonary circulation. Respir. Physiol. 85: 193-204, 1991. PMID:1947459
  32. Kaapa, P., J. U. Raj, B.O. Ibe, and J. Anderson. Effect of Pentoxifylline in rabbit pulmonary circulation: Influence of age and vasomotor tone. Am. J. Physiol. 261: H975-H981, 1991. PMID:1928416
  33. Filler, S., B.O. Ibe, P.M. Luckett, J. U. Raj, and J.E. Edwards, Jr. Candida stimulates endothelial cell eicosanoid production. J. Infect. Dis. 164: 928-935, 1991. PMID:1940471
  34. Raj, J. U., P. Kaapa, and J. Anderson. Age related differences in vascular effects of pentoxifylline isolated perfused ferret lungs. Dev. Pharmacol. Therap. 18: 1-8, 1992. PMID:1483354
  35. Raj, J. U., P. Kaapa, and J. Anderson. Effect of pulsatile flow on microvascular resistance in adult rabbit lungs. J. Appl. Physiol. 72: 73-81, 1992. PMID:1537745
  36. Ibe, B.O., and J. U. Raj. Metabolism of endogenous arachidonic acid by isolated lungs of neonatal and adult rabbits stimulated with calcium ionophore: Effect of hypoxia. Exp. Lung Res. 18: 69-85, 1992. PMID:1572326
  37. Raj, J. U., and J. Anderson. Regional differences in interstitial fluid albumin concentration in edematous lamb lungs. J. Appl. Physiol. 72: 699-705, 1992. PMID:1559950
  38. Ibe, B.O., and J. U. Raj. Endogenous arachidonic acid metabolism by calcium ionophore stimulated ferret lungs: effect of age, hypoxia. Lab. Invest. 66: 370-377, 1992. PMID:1538590
  39. Raj, J. U., H. Toga, B.O. Ibe, and J. Anderson. Effects of endothelin, platelet activating factor and thromboxane A2 in ferret lungs. Respir. Physiol. 88: 129-140, 1992. PMID:1626132
  40. Toga, H., B.O. Ibe, and J. U. Raj. In vitro responses of ovine intrapulmonary arteries and veins to endothelin-1: effect of age. Am. J. Physiol. 263: L15-L21, 1992. PMID:L1636725
  41. Toga, H., S. Hibler, B.O. Ibe, and J. U. Raj. Vascular effects of platelet activating factor in lambs: role of cyclo- and lipoxygenase. J. Appl. Physiol. 73: 2559-2566, 1992. PMID:1490969
  42. Cummings, J.J., D.P. Carlton, F.P. Poulain, J. U. Raj and R.D. Bland. Hypoproteinemia slows lung liquid clearance in young lambs. J. Appl. Physiol. 74:153-160, 1993. PMID: 8444686
  43. Bansal, V., H. Toga, and J. U. Raj. Tone dependent nitric oxide production in ovine vessels in vitro. Respir. Physiol. 93: 249-260, 1993. PMID:8210762
  44. Ibe, B.O., J. Kurantsin-Mills, J. U. Raj, and L.S. Lessin. Plasma and urinary leukotrienes in sickle cell disease: Possible role in the inflammatory process. Europe. J. Clin. Invest. 24:57-64, 1994. PMID:7993800
  45. Filler, S.G., B.O. Ibe, A.S. Ibrahim, M.A. Ghannoum, J. U. Raj, and J.E. Edwards, Jr. Mechanisms by which Candida albicans induces endothelial cell prostaglandin synthesis. Infection and Immunity. 62:1064-69, 1994. PMID:8112841
  46. Ibe, B.O., and J. U. Raj. Metabolism of N-Methylcarbazole by rat lung microsomes. Exp. Lung Res. 20:207-22, 1994. PMID:L7925139
  47. Kurantsin-Mills, J., B.O. Ibe, J. U. Raj, and L.S. Lessin. Elevated plasma and urinary levels of thromboxane metabolites in sickle cell disease: Evidence for activated platelets in the circulation. Br. J. Hematology. 87:580-85, 1994. PMID:7993800
  48. Gao, Y., H. Zhou, and J. U. Raj. Heterogeneity in role of endothelium-derived NO in pulmonary arteries and veins of full-term fetal lambs. Am. J. Physiol. 268:H1586-H1592, 1995. PMID:7733359
  49.  Gao, Y., H. Zhou, and J. U. Raj. Endothelium-derived nitric oxide plays a larger role in pulmonary veins than in arteries of newborn lambs. Circ. Res. 76:559-565, 1995. PMID:7895331
  50. Ibe, B.O., and J. U. Raj. Developmental differences in production of lipoxygenase metabolites by ovine lungs. Exp. Lung Res. 21:385-405, 1995. PMID:7921776
  51. Gao, Y., H. Zhou, and J. U. Raj. PAF induces relaxation of pulmonary arteries but contraction of pulmonary veins in the ferret. Am. J. Physiol. 269:H704-H709, 1995. PMID:7653635
  52. Ibe, B.O., A.C. Okogbule-Wonodi, and J. U. Raj. Antenatal glucocorticoid treatment attenuates immediate postnatal prostacyclin and thromboxane levels in plasma of very preterm lambs. Biology of the Neonate. 69:153-164, 1996. PMID:8672599
  53.  Hibler, S., H. Toga, and J. U. Raj. Differential role of endothelium derived nitric oxide in regulation of the systemic and pulmonary circulations in lambs. Biology of the Neonate. 69:84-93, 1996. PMID:8713653
  54. Matsuda, M., J. Anderson-Morris, and J. U. Raj. Microvascular pressures in isolated perfused immature lamb lungs: Effects of flow rate, left atrial pressure and surfactant therapy. Biology of the Neonate, 70:349-358, 1996. PMID:9001696
  55. Gao, Y., H. Zhou and J. U. Raj. Antenatal betamethasone potentiates nitric oxide-mediated relaxation of preterm ovine coronary arteries. Am. J. Physiol. 270:H538-H544, 1996. PMID:8779828
  56. 56. Zhou, H., Y. Gao, and J. U. Raj. Antenatal betamethasone therapy augments nitric oxide-mediated relaxation of preterm ovine pulmonary veins. J. Appl. Physiol. 80:390-396, 1996. PMID:8929574
  57. Salva, A.M., B.O. Ibe, E. Cliborn, G. Reyes, and J. U. Raj. Hypoxia attenuates metabolism of platelet activating factor by fetal and newborn lamb lungs. J. Lipid Res. 37:783-89, 1996. PMID:8732778
  58. Ibe, B.O., R. Hillyard, and J. U. Raj. Heterogeneity in prostacyclin and thromboxane synthesis in ovine pulmonary vascular tree: Effect of age and oxygen tension. Exp. Lung Res. 22:351-374, 1996. PMID:8792126
  59. Toga, H., V. Bansal, and J. U. Raj. Differential responses of ovine intrapulmonary arteries and veins to acetylcholine. Respir. Physiol. 104: 197-204, 1996. PMID:8893365
  60. Gao, Y., H. Zhou, B.O. Ibe, and J. U. Raj. Prostaglandin E2 and I2 cause greater relaxations in pulmonary veins than in arteries of newborn lambs. J. Appl. Physiol. 81:2534-2539, 1997. PMID:9018503
  61.  Ibe, B.O., J. Morris, J. Kurantsin-Mills, and J. U. Raj. Sickle erythrocytes induce prostacyclin and thromboxane synthesis by isolated perfused rat lungs. Am J. Physiol 272: L597-L602, 1997. PMID:9142930
  62. Ibe, B.O., J.M. Anderson, and J. U. Raj. Leukotriene synthesis by isolated perinatal ovine intrapulmonary vessels correlates with age-related changes in 5-lipoxygenase protein. Biochem Mol. Med. 61: 63-71, 1997. PMID:9232199
  63. S. Oh, B.O. Ibe, C. Johnson, J. Kurantsin-Mills, and J. U. Raj. Platelet activating factor in plasma of sickle cell disease patients in steady state. J. Lab. Clin. Med. 130:191-6, 1997. PMID:9280146
  64. Gao, Y. H. Zhou, J-F. Tolsa, H. Shen, and J. U. Raj. Antenatal betamethasone therapy augments isoproterenol and prostaglandin E2-mediated relaxation of preterm ovine pulmonary veins. Ped. Res. 42:545-549, 1997. PMID:9380451
  65. Gao, Y., J-F. Tolsa, H. Shen, and J. U. Raj. Effect of selective phosphodiesterase inhibitors on response of ovine pulmonary arteries to prostaglandin E2. J. Appl. Physiol. 84:13-18, 1998. PMID:9451612
  66. Gao, Y., J-F. Tolsa, H. Shen, and J. U. Raj. Single dose of antenatal betamethasone enhances isoprenaline and prostaglandin E2-induced relaxation of preterm ovine pulmonary arteries. Biol. Neonate. 73:182-189, 1998. PMID:9535536
  67.  Gao Y, J-F. Tolsa, M. Botello and J. U. Raj. Developmental change in isoproterenol-mediated relaxation of pulmonary veins of fetal and newborn lambs. J Appl Physiol. 84:1535-1539, 1998. PMID:9572796
  68.  Ibe, B.O., S. Hibler, and J. U. Raj. Platelet activating factor modulates pulmonary vasomotor tone in the perinatal lamb. J. Appl. Physiol. 85:1079-85, 1998. PMID:9729586
  69.  Gao, Y., J-F. Tolsa, and J. U. Raj. Heterogeneity in endothelium-derived nitric oxide-mediated relaxation of different sized pulmonary arteries of newborn lambs. Ped. Res. 44:723-729, 1998. PMID:9803454
  70. Okogbule-Wonodi, A.C., B.O. Ibe, B. W. Yue, S. Hsu, and J. U. Raj. Phosphodiesterase activity in intrapulmonary arteries and veins of perinatal lambs. Mol. Gen. Met. 65: 229-237, 1998. PMID:9851888
  71.  Y. Gao, S.R. Dhanakoti, J-F Tolsa, and J. U. Raj. Role of protein kinase G in nitric oxide- and cGMP-induced relaxation of newborn ovine pulmonary veins. J. Appl. Physiol. 87:993-998, 1999. PMID:10484568
  72. Tolsa, J-F., Y. Gao, and J. J U. Raj. Developmental change in magnesium sulfate-induced relaxation of rabbit pulmonary arteries. J. Appl. Physiol. 87:1589-1594, 1999. PMID:10562595
  73. Ibe, B.O., F.C. Sander, and J. U. Raj. Platelet activating factor acetylhydrolase activity in lamb lungs is up-regulated in the immediate newborn period. Mol Genet Metab 69:46-55, 2000. PMID:10655157
  74. Kolber, K., Y. Gao, and J.J U. Raj. Maturational changes in endothelium-derived nitric oxide-mediated relaxation of ovine pulmonary arteries. Biology of the Neonate. 77:123-130, 2000. PMID:10657691
  75. Ibe, B.O., F. C. Sander, and J. U. Raj. Platelet-activating factor receptors in lamb lungs are down-regulated immediately after birth. Am J Physiol 278:H1168-1176, 2000.PMID:10749711
  76. Dhanakoti, S.R., Y. Gao, MQ Nguyen, and J. U. Raj. Involvement of cGMP-dependent protein kinase in the relaxation of ovine pulmonary arteries to cGMP and cAMP. J. Appl. Physiol, 88:1637-1642, 2000. PMID:10797124
  77. Gao, Y., and J. U. Raj. SQ22536 and W-7 inhibit Forskolin-induced cAMP elevation but not relaxation in newborn ovine pulmonary veins. Eur. J. Pharm. 418: 111-116, 2001. PMID:11334872
  78. Ibe, B.O., and J. U. Raj. Leukotriene Metabolism by Intrapulmonary Vessels of Newborn Lambs: Effect of Platelet Activating Factor. Exp. Lung Res. 27: 331-48, 2001. PMID:11400860
  79. Ibe, B.O., H.H. Pham, P. Kaapa, and J. U. Raj. Maturational changes in ovine pulmonary metabolism of Platelet Activating Factor: Implications for Postnatal adaptation. Mol Gen Metabolism, 74: 385-95, 2001. PMID:11708870
  80. Ibe, B.O., A. M. Portugal, and Usha Raj J. Metabolism of platelet activating factor by intrapulmonary vascular smooth muscle cells. Effect of oxygen on phospholipase A2 protein expression and activities of acetyl-CoA acetyltransferase and cholinephosphotransferase. Mol. Gen. Metabolism, 77:237-248, 2002. PMID:12409272
  81. Gao, Y., and Usha Raj J. Effects of SQ22536, an adenylyl cyclase inhibitor, on isoproterenol-induced cAMP elevation and relaxation in newborn ovine pulmonary veins. Eur. J. Pharm. 436:227-233, 2002.
  82. Raj, U. and L. Shimoda. Oxygen-dependent signaling in pulmonary vascular smooth muscle. AJP: Lung Cell Mol Physiol 283:L671-677, 2002. PMID 12225941
  83. Tolsa, Jean-Francois, Y. Gao, F. Sander, A-C. Souici, A. Moessinger, and J. U. Raj. Differential responses of pulmonary arteries and veins of newborn lamb to Atrial and C-type natriuretic peptides. Am. J. Physiol, 282:H273-H280, 2002. PMID:11748072
  84. Gao, Y., S.N. Dhanakoti, E.M. Trevino, F.C. Sander, A.M. Portugal, and J. U. Raj. SN, Effect of oxygen on cyclic GMP-dependent protein kinase-mediated relaxation in ovine fetal pulmonary arteries and veins. AJP: Lung Cell Mol Physiol, 285:L611-L618, 2003. PMID:12754191
  85. Gao, Y., S.N. Dhanakoti, E.M. Trevino, X. Wang, F.C. Sander, A.M. Portugal, and J. U. Raj. Role of cGMP-dependent Protein Kinase in development of tolerance to nitric oxide in pulmonary veins of newborn lambs. AJP: Lung Cell Mol Physiol 286:L786-92, 2004. PMID:14660486
  86. Joyce, J.J., P.I. Dickson, N.Qi, J.E. Noble, J.J U. Raj, and B.G. Baylen. Normal right and left ventricular mass development during early infancy. Am J Cardiol 15:93(6):797-801, 2004. PMID:15019899
  87. Ibe, B.O., A.M. Portugal, S. Chaturvedi, and J. U. Raj. Oxygen-dependent PAF-receptor binding and intracellular signaling in ovine fetal pulmonary vascular smooth muscle. AJP: Lung Cell Mol Physiol, 288(5):L879-86, 2005. PMID:15618453
  88. Y. Gao and J.  U. Raj. Role of Veins in Regulation of the Pulmonary Circulation. AJP: Lung Cell Mol Physiol, 288:L213-26, 2005. PMID:15640520
  89. Gao,Y. and J.  U. Raj. "Parathyroid Hormone Related Protein Mediated Responses in Pulmonary Arteries and Veins of Newborn Lambs". AJP: Lung Cell Mol Physiol , 289: L60-66, 2005. PMID:15749740
  90. Sander, F., Y. Gao, and J. J U. Raj. Hypoxia down-regulates cyclic guanidine monophosphate-dependent protein kinase in fetal pulmonary vascular smooth muscle cell through generation of reactive oxygen species and promotes development of pulmonary hypertension. Chest,128:577S-578S, 2005. PMID:16373839
  91. Wang, X., M. Tong, S. Chinta, J.  U. Raj, and Y. Gao. Hypoxia-induced Reactive Oxygen Species Downregulate ETB-receptor-mediated Contraction of Rat Pulmonary Arteries. AJP: Lung Cell Mol Physiol, 290:L570-8. 2006. PMID:16221721
  92. John, T. A., B.O. Ibe, and J. U. Raj. Oxygen alters Caveolin-1 and Nitric Oxide Synthase-3 functions in ovine fetal and neonatal lung microvascular endothelial cells. AJP: Lung Cell Mol Physiol, 291(5):L1079-93, 2006. PMID:16997880
  93. Ibe, B.O., A. Portugal, and J. U. Raj. Levalbuterol inhibits human airway smooth muscle cell proliferation: therapeutic implications in management of asthma. Int Arch Allergy and Immunology, 139:225-36, 2006. PMID:16446544
  94. Ibe, B.O., A. Ameer, A. M. Portugal, L. Renteria, and J. U. Raj. Platelet Activating Factor Modulates Activity of Cyclic Nucleotides in Fetal Ovine Pulmonary Vascular Smooth Muscle. J Pharmacol Exp Therap, 320(2):728-37. 2007. PMID:16446544
  95. Zhou, W., C. Dasgupta, S. Negash, and J. U. Raj. Modulation of Pulmonary Vascular Smooth Muscle Phenotype in Hypoxia: Role of cGMP-Dependent protein Kinase. AJP: Lung Cell Mol Physiol; 292(6):L1459-66, 2007. PMID:17322285
  96. Gao, Y., A. Portugal, S. Negash, W. Zhou, L.D. Longo, and Usha Raj J. Role of Rho Kinases in PKG-Mediated Relaxation of Pulmonary Arteries of Fetal Lambs Exposed to Chronic High Altitude Hypoxia. AJP: Lung Cell Mol Physiol, 292: L678 - L684, 2007. PMID:17085525
  97. Zhou, W., B.O. Ibe, and J. U. Raj. Platelet Activating Factor induces Ovine Fetal Pulmonary Venous Smooth Muscle Cell Proliferation: Role of Epidermal Growth Factor Receptor transactivation. AJP: Heart Circulation Physiol; 292(6):H2773-81, 2007. PMID:17322418
  98. Qin, X., X. Zheng, H. Qi, D. Dou, J.  U. Raj, and Y. Gao. cGMP-Dependent Protein Kinase in Regulation of Basal Tone and in Nitroglycerin and Nitric Oxide Induced Relaxation in Porcine Coronary Artery. Pflugers Arch Euro Journal Physiol; 454(6):913-23, 2007. PMID 17377806
  99. Raj, J. U., et al. Genomics and Proteomics of Lung Disease: Conference Summary. AJP: Lung Cell Mol Physiol; 293(1):L45-5, 2007. PMID:17468134
  100. Negash, S., Y. Gao, W. Zhou, S. Chinta, J. Liu, and J. U. Raj. Regulation of cGMP-Dependent Protein Kinase (PKG1) Mediated Vasodilation by Hypoxia-Induced Reactive Species in Ovine Fetal Pulmonary Veins. AJP: Lung Cell Mol Physiol; 293(4):L1012-20, 2007. PMID:17616649
  101. Qi, H., X. Zheng, X. Qin, D. Dou, H. Xu, J. U. Raj, and Y. Gao. PKG Regulates the Basal Tension and Plays a Major Role in Nitrovasodilator-Induced Relaxation of Porcine Coronary Veins. British J Pharmacol; 152(7):1060-9, 2007. PMID:17891157
  102. Bixby, C.E., B.O. Ibe, M.F. Abdallah, A.A. Hislop, L.D. Longo, and J. U. Raj. Role of Platelet Activating Factor in Pulmonary Vascular Remodeling Associated with Chronic High-Altitude Hypoxia in Ovine Fetal Lambs, AJP: Lung Cell Mol Physiol; 293(6):L1475-82, 2007. PMID:17951313
  103. John, T.A., B.O. Ibe and J.J U. Raj. Regulation Of Endothelial Nitric Oxide Synthase: Involvement of Protein Kinase G ß, Serine 116 Phosphorylation And Lipid Structures. Clinical and Experimental Pharmacology and Physiology; 35(2):148-58, 2008. PMID:17892503
  104. Dou, D., X. Zheng, X. Qin, H. Qi, L. Liu, J. U. Raj, and Y. Gao. Role of PKG in Development of Nitroglycerin Tolerance of Porcine Coronary Arteries. British Journal of Pharmacology; 153(3):497-507, 2008. PMID:1803790
  105. Ibe, B.O., M. Abdallah, A. D. Portugal, and J. U. Raj. Platelet Activating Factor stimulates ovine fetal pulmonary vascular smooth muscle cell proliferation: Role of nuclear factor-kappa beta and cyclin dependent kinases. Cell Proliferation; 41(2):208-29, 2008. PMID 18336468
  106. Ibe, B.O., M. Abdallah, and J. U. Raj. Mechanisms by which (S)-albuterol induces human bronchial smooth muscle cell proliferation. Int Arch Allergy and Immunology; 146(4):321-333, 2008. PMID:18362475
  107. Gao, Y., A.D. Portugal, J. Liu, S. Negash, W. Zhou, J. Tian, R. Xiang, L. D. Longo, and J.U. Raj. Preservation of cGMP-induced relaxation of pulmonary veins of fetal lambs exposed to chronic high altitude hypoxia: role of PKG and Rho kinase. AJP: Lung Cell Mol Physiol, 295(5):L889-96, 2008. PMID:18757523
  108. Abman S, Jobe A, Chernick V, Blaisdell C, Castro M, Ramirez MI, Gern JE, Cutting G, Redding G, Hagood JS, Whitsett J, Abman S, J U. Raj, Barst R, Kato GJ, Gozal D, Haddad GG, Prabhakar NR, Gauda E, Martinez FD, Tepper R, Wood RE, Accurso F, Teague WG, Venegas J, Cole FS, Wright RJ, Gail D, Hamvas A, Kercsmar C, Kiley J, Weinmann G; NHLBI working group report. Strategic plan for pediatric respiratory diseases research: an NHLBI working group report, Pediatric Pulmonol, 44(1):2-13, 2009. PMID:19086051
  109. Castro M, Ramirez MI, Gern JE, Cutting G, Redding G, Hagood JS, Whitsett J, Abman S, J U. Raj, Barst R, Kato GJ, Gozal D, Haddad GG, Prabhakar NR, Gauda E, Martinez FD, Tepper R, Wood RE, Accurso F, Teague WG, Venegas J, Cole FS, Wright RJ. Strategic plan for pediatric respiratory diseases research: an NHLBI working group report Proc Am Thorac Soc. 15;6(1):1-10, 2009. PMID:19131525
  110. Liu, J., Y. Gao, S. Negash, L.D. Longo, and J. U. Raj. Long-term effects of prenatal hypoxia on endothelium-dependent relaxation responses in pulmonary arteries of adult sheep. AJP: Lung Cell Mol Physiol, Mar; 296(3):L547-54, 2009. PMID:19136582
  111. Zhou, W., S. Negash, J. Liu, and J. U. Raj. Modulation of Pulmonary Vascular Smooth Muscle Cell phenotype in hypoxia: Role of cGMP-Dependent Protein Kinase and Myocardin. AJP: Lung Cell Mol Physiol, May;296(5):L780-9; 2009. MID:19251841
  112. Negash, S., S. R.Narasimhan, W. Zhou, J. Liu, F. Wei, and J. U. Raj. Role of cGMP-dependent protein kinase (PKG) in regulation of ovine fetal pulmonary vascular smooth muscle cell adhesion and migration: Effect of hypoxia. AJP: Lung Cell Mol Physiol, Jul;297(1):H304-12, 2009. PMID:19411288
  113. Sheng, L., W. Zhou, A. A. Hislop, L. D. Longo, B.O. Ibe, and J. U. Raj. Role of Epidermal Growth Factor Receptor in Ovine Fetal Pulmonary Vascular Remodeling Following Exposure to High Altitude Long-Term Hypoxia". High Altitude Medicine & Biology, 10 (4): 365-72, 2009. PMID:20043379
  114. S.H. Abman and J U. Raj. Towards improving the care of children with pulmonary hypertension: The rationale for developing a Pediatric Pulmonary Hypertension Network. Progress in Pediatric Cardiology. 27:3-6, 2009.
  115. Ma, H., Q. He. D. Dou, X. Zheng, L. Ying, Y. Wu, and J. U. Raj, and Y. Gao. Increased Degradation of MYPT1 Contributes to the Development of Tolerance to Nitric Oxide in Porcine Pulmonary Artery. AJP: Lung Cell Mol Physiol, 299:L117-23, 2010. PMID: 20418385
  116. John, T.A., and J. U. Raj. A fluorescence-activated cell sorter analysis of the relationship between protein kinase G and endothelial nitric oxide synthase. The Anatomical Record, 293: 1755-65, 2010. PMID:20652958
  117. Sarkar J., D. Gou, P. Turaka, E. Viktorova, R. Ramchandran, and J. U. Raj. MicroRNA-21 plays a Role in Hypoxia-mediated Pulmonary Artery Smooth Muscle Cell Proliferation and Migration. AJP: Lung Cell Mol Physiol, 299:L861-71, 2010. PMID:20693317
  118. Renteria, L.S., J. U. Raj and B.O. Ibe. Prolonged hypoxia modulates platelet activating factor receptor-mediated responses by fetal ovine pulmonary vascular smooth muscle cells. Molecular Genetics and Metabolism, 101:400-8, 2010. PMID:20813571
  119. Gao, Y. and J. U. Raj. Development and Regulation of the Circulation in the Fetus and Newborn. Physiological Reviews, 90:1291-335, 2010. PMID:20959607
  120. Gao Y, and J. U. Raj. Hypoxic Pulmonary Hypertension of the Newborn. Compr Physiol 1:61-79, 2011. PMID:23737164
  121. Zhou, Q., T. Chen, J.C. F. Ibe, J. U. Raj, and G. Zhou. Loss of either hypoxia inducible factor 1 or 2 promotes lung cancer cell colonization. Cell Cycle. 10(13):2233-4, 2011. PMID: 21610325
  122. Zhou, Q., A. Pardo, M. Koenigshoff, O. Eickelberg, G.R.S. Budinger, K. Thavarajah, C.J. Gottardi, J. Jones, J. Varga, M. Selman, J. I. Sznajder, J. U. Raj and G. Zhou. Role of von Hippel-Lindau in fibroblast proliferation and fibrosis. Faseb J. (9):3032-44, 2011. PMID:21642472
  123. Cerro MJ, Abman S, Diaz G, Freudenthal AH, Freudenthal F, Harikrishnan S, Haworth SG, Ivy D, Lopes AA, J U. Raj, Sandoval J, Stenmark K, Adatia I. A consensus approach to the classification of pediatric pulmonary hypertensive vascular disease: Report from the PVRI Pediatric Taskforce, Panama 2011. Pulm Circ. 1(2):286-298, 2011. PMID:21874158
  124. Lammers AE, Adatia I, Cerro MJ, Diaz G, Freudenthal AH, Freudenthal F, Harikrishnan S, Ivy D, Lopes AA, J U. Raj, Sandoval J, Stenmark K, Haworth SG. Functional classification of pulmonary hypertension in children: Report from the PVRI pediatric taskforce, Panama 2011. Pulm Circ. Aug 2;1(2):280-285, 2011. PMID:21874157
  125. Adebola TJ, and Usha R. Inhibitors caveolin-1 and protein kinase G show differential subcellular colocalization with Nitric oxide synthase. Afr. Health Science. 4:526-34, 2011. PMID:22649431
  126. Singh, D.K., J. Sarkar, A, Raghavan and J. U. Raj. Hypoxia modulates the expression of leucine zipper positive MYPT1 and its interaction with protein kinase G and Rho kinases in pulmonary arterial smooth muscle cells. Pulmonary Circulation, 1:487-98, 2011. PMID:22530104
  127. Ramchandran, R., E. Pilipenko, L. Bach, and J. U. Raj. Hypoxia regulation of pulmonary vascular smooth muscle cGMP-dependant kinase by the ubiquitin conjugating system. Amer. J. of Respir. Cell and Mol. Biology, 46:323-30, 2012. PMID:21997485
  128. Raghavan, A., G. Zhou, Q. Zhou, J.C.F. Ibe, R. Ramachandran, H. Racherla, P. Raychaudhuri, and J. U. Raj. Hypoxia induced pulmonary arterial smooth muscle cell proliferation is controlled by FoxM1. Amer. J. of Respir. Cell and Mol. Biology, 46:431-6, 2012. PMID:22033266
  129. Bae, R., A. Arteaga, J. U. Raj and B.O. Ibe. Albuterol isomers modulate platelet activating factor synthesis, receptor signaling and leukotriene release in human bronchial smooth muscle cells. International Archives of Allergy and Immunology, 158:18-26, 2012. PMID:22212397
  130. Peng, X., Y. Wang, S. Kolli, J. Deng, L. Li, Z. Wang, J. U. Raj, and D. Gou. Physical and functional interaction between the ID1 and p65 for activation of NFκB. AJP: Cell Physiology, 303:C267-77, 2012. PMID:22592405
  131. Zhou, Q., T. Chen, J.C. Ibe, J. J U. Raj, and G. Zhou. Knockdown of von Hippel-Lindau Protein decreases lung cancer cell proliferation and colonization. FEBS Lett. 586:1510-5, 2012. PMID:22673518.
  132. Hobin J.A., A.M. Deschamps, R. Bockman, S. Cohen, P. Dechow, C. Eng, W. Galey, M. Morris, S. Prabhakar, J U. Raj, P. Rubinstein, J.A. Smith, P. Stover, N. Sung, W. Talman, and R. Galbraith. Engaging basic scientists in translational research: identifying opportunities, overcoming obstacles. J. Transl. Med.10:72, 2012. PMID:22500917
  133. Yang, Q., Z. Lu, D. Singh, and J. U. Raj. BIX-01294 treatment blocks cell proliferation, migration and contractility in ovine foetal pulmonary arterial smooth muscle cells. Cell Proliferation, 45:335-44, 2012.PMID:22691107
  134. Gu, S., Y. Tian, A. Chlenski, H.R. Satwen, Z. Lu, J. U. Raj, and Q. Yang. Valproic acid shows a potent antitumor effect with alteration of DNA methylation in neuroblastoma. Anticancer Drugs, 23: 1054-66, 2012. PMID:22863973
  135. Gou, D., R. Ramchandran, X. Peng, L. Yao., K. Kang, J. Sarkar, Z. Wang, G. Zhou, and J. U. Raj. MiR-210 has an anti-apoptotic effect in pulmonary artery smooth muscle cells during hypoxia. AJP: Lung Cell Mol Physiol, 303:L682-91, 2012. PMID:22886504
  136. Shaikh, D., Q. Zhou, J.C.F. Ibe, T. Chen, J. U. Raj, and G. Zhou. cAMP-dependent protein kinase is essential for hypoxia-mediated epithelial-mesenchymal transition, migration, and invasion in lung cancer cells. Cell Signal, 24:2396-406, 2012. PMID:22954688
  137. Yang, Q., Z. Lu, R. Ramchandran, L.D. Longo, and J. U. Raj. Pulmonary Artery smooth muscle cell proliferation and migration in fetal lambs acclimatized to high-altitude long-term hypoxia: role of histone acetylation. AJP: Lung Cell Mol Physiol, 303: L1001-10, 2012. PMID: 23043075
  138. Xu, X., S. Wang, J. Liu, D. Dou, L. Liu, Z. Chen, L. Ye, H. Liu, Q. He, J. U. Raj, and Y. Gao. Hypoxia induces downregulation of soluble guanylate cyclase β1 by miR-34c-5p. J. Cell Sci. 125:6117-26, 2012. PMID:23038777
  139. Ye, L., J. Liu, H. Liu, L. Ying, D. Dou, Z. Chen, X. Xu, J. U. Raj, and Y. Gao. Sulfhydryl-dependent dimerization of soluble guanylyl cyclase modulates relaxation of porcine pulmonary vessels to nitric oxide. Pflügers Archiv, European Journal of Physiology, 465:333-41, 2013. PMID:23143201
  140. Lu, Z., H.R. Salwen, A. Chlenski, L.A. Godley, J. U. Raj, and Q. Yang. Histone lysine methyltransferase EHMT2 is involved in proliferation, apoptosis, cell invasion and DNA methylation of human neuroblastoma cells. Anticancer Drugs. 24:484-93, 2013. PMID:23466651
  141. Abman, S.A., J.P. Kinsella, E.B. Rosenzweig, U. Krishnan, T. Kulik, M. Mullen, D.L. Wessel, R. Steinhorn, I Adatia, B. Hanna, J. Feinstein, J. Fineman, J U. Raj, T. Humpl. On behalf of the Pediatric Pulmonary Hypertension Network (PPHNet). Implications of the US FDA Warning Against the Use of Sildenafil for the Treatment of Pediatric Pulmonary Hypertension. Am. J. Respir. Crit. Care Med. 187:572-5, 2013. PMID:23220921
  142. Namachivayam, K., C.L. Blanco, B.L. Frost, A.A. Reeves, R. Jagadeeswaran, K. MohanKumar, A. Safarulla, P. Mandal, S.A. Garzon, J. U. Raj, A. Maheshwari. Preterm Human Milk contains a Large Pool of Latent TGF-β, which can be activated by Exogenous Neuraminidase. Am. J. Physiol, Gastro and Liver, 304:G1055-65, 2013. PMID:23558011
  143. Kang, K., X. Peng, X. Zhang, Y. Wang, L. Zhang, L. Gao, T. Weng, H. Zhang, R. Ramchandran, J. U. Raj, D. Gou, L. Liu. MicroRNA-124 suppresses the transactivation of nuclear factor of activated T cells by targeting multiple genes and inhibits the proliferation of pulmonary artery smooth muscle cells. J. Biol. Chem. 288:25414-27, 2013. PMID:23853098
  144. Harijith, A., S. Oendyala, N.M. Reddy, T. Bai, P.V. Usatyuk, E. Berdyshev, I. Gorshkova, L.S. Huang, V. Mohan, S. Garzon, P. Kanteti, S.P. Reddy, J. U. Raj, V. Natarajan. Sphingosine Kinase 1 Deficiency confers protection against hyperoxia-induced bronchopulmonary dysplasia in a murine model: Role of SP1 signaling and Nox proteins. Am. J. Pathol. 183:1169-82, 2013. PMID:23933064
  145. Yang, Q., M.J. Dahl, K.H. Albertine, R. Ramachandran, M. Sun, J. U. Raj. Role of histone deacetylases in regulation of phenotype of ovine newborn pulmonary arterial smooth muscle cells. Cell Proliferation. 46, 654–664, 2013. PMID:24460719
  146. Ibe, J. C. F., J. U. Raj, Q. Zhou, T. Chen, G. Zhou. AMPK is required for pulmonary artery smooth muscle cell survival and the development of hypoxic pulmonary hypertension. Am. J. Resp. Cell Mol. Biol. 49:6-09-18, 2013. PMID: 23668615
  147. Mezu-Ndubuisi, O. J., J. Wanek, F.Y. Chau, P. Teng, N.P. Blair, N.M. Reddy, J. U. Raj, S.P. Reddy, M. Shahidi. In-vivo Retinal Vascular Oxygen Tension Imaging and Fluorescein Angiography in the Mouse Model of Oxygen-Induced Retinopathy. Investigative Ophthalmology and Visual Science.54:6968-72, 2013. PMID: 24052641
  148. Renteria, L.S., Austin, M., Lazaro, M., Andrews, M.A., Lustina, J., Raj, J. U., Ibe, B. RhoA-Rho kinase and Platelet-Activating Factor Stimulation of Ovine Fetal Pulmonary Vascular Smooth Muscle Cell Proliferation. Cell Prolif. 46:563-75, 2013. PMID:24033386
  149. Ivy, D.D., Abman, S.H., Barst, R.J., Berger, R.M., Bonnet, D., Fleming, T.R., Haworth, S.G., Raj, J.U., Rosenzweig, E.B., Schulze Neick, I., Steinhorn, R.H., Beghetti, M. Pediatric Pulmonary Hypertension. J Am Coll Cardiol. 62:D117-26, 2013. PMID: 24355636
  150. Mezu-Ndubuisi, O. J., J. Wanek, F.Y. Chau, P. Teng, N.P. Blair, N.M. Reddy, Raj, J.U., Reddy, S.P., Shahidi, M.. Correspondence of Retinal Thinning and Vasculopathy in Mice with Oxygen-Induced Retinopathy. Exper. Eye Res. 122:119-22, 2014. PMID:24703909
  151. Ramchandran, R., Raghavan, A., Geenan, D., Sun, M., Bach, L., Yang, Q., Raj, J.U. PKG1α leucine zipper domain defect increases pulmonary vascular tone: implications in hypoxic pulmonary hypertension. Am. J. Physiol. Lung Cell. and Mol. Phys. L537-44, 2014. PMID:25128522.
  152. Chen, J., Tang, H., Sysol, J., Moreno-Vinasco, L., Shioura, K., Chen, T., Gorshkova, I., Wang, L., Huang, L., Usatyuk, P., Sammani, S., Zhou, G., Raj, J.U., Garcia, JGN, Berdyshev, E., Yuan, J., Natarajan, V., Machado, R. The Sphingosine Kinase 1 / Sphingosine-1-Phosphate Pathway in Pulmonary Arterial Hypertension. Am. J. Resp. Critical Care Med. In Press, 2014. PMID: 25180446
  153. Zhou, G., Chen, T., Raj, J.U. MicroRNAs in Pulmonary Hypertension. Am. J. Resp. Cell Mol Biol. In Press, 2014. PMID: 25192340
  154. Zeng, Y., Pan, Y., Liu, H., Kang, K., Wu, Y., Hui, G., Peng, W., Ramchandran, R., Raj, J.U., Gou, D. MiR-20a regulates the PRKG1 gene by targeting its coding region in pulmonary arterial smooth muscle cells. FEBS Letters, In Press, 2014.
  155. T. Chen, Zhou, G., Zhou, Q., Tang, H., Ibe, J.C.F., Cheng, H., Gou, D., Chen, J., Yuan, X-J., Raj, J.U. Loss of miR-17~92 in smooth muscle cells attenuates experimental pulmonary hypertension via induction of PDLIM5. Am. J. Resp. Crit. Care. In Press, 2015.
  156. SUBMITTED MANUSCRIPTS

  157. Zeng, Y., Liu, H., Pan, Y., Hui, G., Raj, J.U. Gou, D. MicroRNA-9 enhances the transactivation of nuclear factor of activated T cells by targeting KPNB1 and DYRK1B C-00299-2014

 

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BOOKS/CHAPTERS/INVITED REVIEWS

  1. Raj. J. Usha.  Hyaline membrane disease.  In: Neonatal Cardiopulmonary Distress, G. C. Emmanouilides and B.G. Baylen, eds., Yearbook Medical Publishers, Inc., 1987, pp 49-64.
  2. Raj, J. Usha, and G. Franco.  Acid Base, Fluid and Electrolyte Management. In: Schaffer and Avery's Diseases of the Newborn. eds. W. Taeusch, R. Ballard and M.E. Avery.  6th Ed. 1991. W. B. Saunders Company, Harcourt Brace Jovanovitch, Inc. Philadelphia, PA 19106.
  3. Raj, J. Usha. The Role of Physical Factors and Lung Water on Microvascular Pressures and Pulmonary Vascular Resistance. In Proceedings of 100th Anniversary Celebration, Children’s Hospital, Groningen, Holland. Pp 54-59, 1993.
  4. Raj, J. Usha. Effect of the Distribution of Vascular Pressures on Pulmonary Edema. In: Pulmonary Edema. ed. E.K. Weir, J.T. Reeves, Futura Publishing Company, New York. Pp 183-194, 1998 
  5. J-F. Tolsa, J-L. Micheli, Y Gao, and J. Usha Raj. Corticoids antenatals: effets sur l’adapation respiratoire et cardiocirculatoire des nouveau-nes prematures. In: Progres en pediatrie perinatalogie. 7 Le poumon du nouveau-ne”, ed. M. Dehan, J-L. Micheli, Pp 39-47, 2000.
  6. Raj, J. Usha, Y. Gao, S. Dhanakoti and F. Sander. Nitric Oxide and Intracellular Signaling in Lung Vascular Smooth Muscle Cells. Progres en pediatrie perinatalogie, 2004
  7. Raj, J. Usha, Y. Gao, S. Dhanakoti and F. Sander. cGMP-dependent protein kinase in regulation of the perinatal pulmonary circulation. Futura Publishing Company, New York, 2005.
  8. Wang, X, M. Tong, D. Dou, J. U. Raj, and Y. Gao. Role of cGMP-dependent Protein Kinase in the Cardiovascular System. Sheng Li Ke Xue Jin Zhan, Chinese Physiological Society, 36: 299-303, 2005.
  9. Invited Review: Y. Gao and J. U. Raj. cGMP-dependent protein kinase in regulation of the pulmonary circulation. Current Resp Med Reviews, 2:373-381, 2006.
  10. Y. Gao and J. U. Raj. Endothelial Regulation of the Pulmonary Circulation in the Fetus and Newborn. The Pulmonary Endothelium; Function in Health and Disease, Eds. Voelkel and Rounds. Wiley Blackwell, 381-398, 2009.
  11. Y. Gao and J. U. Raj. Hypoxic pulmonary hypertension of the newborn. Comprehensive Physiology, American Physiological Society, 2010.
  12. J. U. Raj and J. R. Wright. Respiratory Distress Syndrome. Pp197-207. Breathing in America: Diseases, Progress and Hope. Ed. D.E. Schraufnagel, ATS Publication, 2010.

 

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